Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
148 words
A compound of the formula: wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, lower cycloalkyl, adamantyl, or a phenyl or benzyl group in which the benzene ring is optionally mono-substituted with halogen, hydroxy, lower alkyl, lower alkoxy or trifluoromethyl; R 3 is hydrogen, lower alkyl, allyl, 3-methyl-allyl, lower cycloalkyl-methyl, lower cycloalkyl-ethyl, lower alkoxylower alkyl, di(lower alkyl)amino-lower alkyl, lower alkanoyl, lower cycloalkyl-carbonyl, or a benzyl or benzoyl group in which the benzene ring is optionally substituted as in R 2 R 4 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, trifluoromethyl, di(lower alkyl)amino, or a • benzyloxy group in which the benzene ring is optionally substituted as in R 2 ; with the proviso that at least one of R 1 , R2, R 3 and R 4 is other than hydrogen; and the pharmaceutically acceptable acid addition salts and bio- precursors thereof.
Claim 2
Dependent Claim
148 words
A compound of the formula: wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, lower cycloalkyl, adamantyl, or a phenyl or benzyl group in which the benzene ring is optionally mono-substituted with halogen, hydroxy, lower alkyl, lower alkoxy or trifluoromethyl; R 3 is hydrogen, lower alkyl, allyl, 3-methyl-allyl, lower cycloalkyl-methyl, lower cycloalkyl-ethyl, lower alkoxylower alkyl, di(lower alkyl)amino-lower alkyl, lower alkanoyl, lower cycloalkyl-carbonyl, or a benzyl or benzoyl group in which the benzene ring is optionally substituted as in R 2 R 4 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, trifluoromethyl, di(lower alkyl)amino, or a • benzyloxy group in which the benzene ring is optionally substituted as in R 2 ; with the proviso that at least one of R 1 , R2, R 3 and R 4 is other than hydrogen; and the pharmaceutically acceptable acid addition salts and bio- precursors thereof.
Claim 3
Dependent Claim
51 words
2 A compound according to claim 1, without the preving. or a pharmaceutically acceptable acid addition salt or bioprecursor therter, for use in treating an animal, including a human being, to inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclo-oxygenase enzymes.
Claim 4
Dependent Claim
15 words
A compound according to claim 1 or claim 2, in which is hydrogen or methyl.
Claim 5
Dependent Claim
30 words
A compound according to any of claims 1 to 3, in which R 3 is hydrogen and R 2 is hydrogen, isopropyl, cyclopropyl, cyclohexyl. benzyl, o- or p-tolyl or c-chloro-phenyl.
Claim 6
Dependent Claim
14 words
A compund according to any of claims 1 to 3, in whioch R 2
Claim 7
Dependent Claim
27 words
A compound according to any of claims 1 to 3, in which R 2 is hydrogen and R 3 is methyl, ethyl, n-propyl, allyl, acetyl orp-methyl-or p-methoxy-benzoyl.
Claim 8
Dependent Claim
16 words
A compound according to any of claims 1 to 5, in which R 4 is hydrogen.
Claim 9
Dependent Claim
28 words
A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable acid addition salt or bioprecursor thereof, together with a pharmaceutically acceptable diluent or carrier.
Claim 10
Dependent Claim
36 words
A pharmaceutical composition in dosage unit form comprising a compound according to any of claims 2 to 6, or a pharmaceutically acceptable acid addition salt or bioprecursor thereof, together with a pharmaceutically acceptable diluent or carrier.
Claim 11
Dependent Claim
47 words
A method of preparing a compound according to claim 1, in which R 3 is hydrogen, which comprises reacting an indole of the formula: wherein R 1 ,R 2 and R 4 are as defined in claim 1 and Z is a good leaving group, with imidazole.
Claim 12
Dependent Claim
52 words
A method of preparing a compound according to claim 1, in which R 3 is other than hydrogen, which comprises reacting the corresponding compound in which R 3 is hydrogen with an appropriate alkylating or acylating agent in the presence of a base which forms the corresponding N-anion of the starting compound.