EP0089003A2
Expired / Lapsed
EP
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Blood purification apparatus
Assignee: Toyota Central R&D Labs Inc
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Filing: 1983-03-09
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Granted: —
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Expires: 2003-03-09
Abstract
Abstract A blood purification apparatus includes an extacorporeal circulation system, a blood purifier provided in the system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulation blood volume measuring instrument for measuring changes in a circulating blood volume within a patient's body, a control section comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, the program being matched to the condition of a patient, and a regulator connected to the extracorporeal circulation system and the control section, for controlling the circulating blood volume, the regulator being controlled by the control section on the basis of the circulating blood volume measured during blood purification and the programmed amount. In this apparatus, optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Inventors
- 👤 Toshikazu Ishihara
- 👤 Tomoyuki Kitano
- 👤 Toru Shinzato
- 👤 Kenji Maeda
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 21:42
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/34; A61M1/3403; A61M1/3406; A61M1/341; A61M1/342; A61M1/3424; A61M1/3427; A61M1/3437; A61M1/3441; A61M1/3451; A61M1/3455; A61M1/3458; A61M1/36; A61M1/3607; A61M1/3609; A61M1/361; A61M1/3621; A61M1/3669; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/3368; A61M2205/3372; A61M2205/50; A61M2205/52; A61M2230/00; A61M2230/20; A61M2230/207
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
167 words
A blood purification apparatus comprising an extracorporeal circulation system (10), and a blood purifier (18, 74) provided in said system for purifying blood by dialysis or filtration through a semipermeable membrane, characterized in that said apparatus further comprises, a circulating blood volume measuring instrument (24) connected to said extracorporeal circulation system, for measuring changes in the circulating blood volume within a patient's body, a control section (14) connected to said circulating blood measuring instrument, comprising a memory (66) for storing a program for a pattern of changes in the circulating blood volume during blood purification, said program being matched to the condition of the patient, and a regulator (28, 80) connected to said extracorporeal circulation system and said control section, for controlling the circulating blood volume, said regulator being controlled by said control section on the basis of the circulating blood volume measured during blood purification and the programmed amount, whereby optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Claim 2
Dependent Claim
167 words
A blood purification apparatus comprising an extracorporeal circulation system (10), and a blood purifier (18, 74) provided in said system for purifying blood by dialysis or filtration through a semipermeable membrane, characterized in that said apparatus further comprises, a circulating blood volume measuring instrument (24) connected to said extracorporeal circulation system, for measuring changes in the circulating blood volume within a patient's body, a control section (14) connected to said circulating blood measuring instrument, comprising a memory (66) for storing a program for a pattern of changes in the circulating blood volume during blood purification, said program being matched to the condition of the patient, and a regulator (28, 80) connected to said extracorporeal circulation system and said control section, for controlling the circulating blood volume, said regulator being controlled by said control section on the basis of the circulating blood volume measured during blood purification and the programmed amount, whereby optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Claim 3
Dependent Claim
76 words
An apparatus according to claim 1, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient's body connected to said control section, wherein said control section further comprises a water removal quantity memory for storing a water removal program and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification and the measured quantity of removed water with programmed values.
Claim 4
Dependent Claim
28 words
An apparatus according to claim 1 or 2 wherein said regulator comprises at least one of a water removal and/or supply regulator and a plasma osmotic pressure regulator.
Claim 5
Independent Claim
111 words
An apparatus according to any one of claims 1 to 3, further comprising a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system and said control section, wherein said regulator comprises a water removal and/or supply regulator and a plasma osmotic pressure regulator, and said control section further comprises a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount and of the measured plasma osmotic pressure with the prescribed value.
Claim 6
Dependent Claim
87 words
An apparatus according to claim 4, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient's body, wherein said control section further comprises a water removal quantity memory for storing a water removal program, and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount, of the measured plasma osmotic pressure with the prescribed value, and of the measured amount of removed water with the programmed amount.
Claim 7
Independent Claim
37 words
An apparatus according to any one of claims 3 to 5, wherein said plasma osmotic pressure regulator comprises a means for controlling the infusing rate of hyper and/or hypo osmolal solution to control the plasma osmotic pressure.
Claim 8
Independent Claim
32 words
An apparatus according to any one of claims 3 to 6, wherein said plasma osmotic pressure regulator comprises a means for varying the electrolytic concentration of a dialysate or a replacement fluid.
Claim 9
Dependent Claim
26 words
An apparatus according to claim 4 or 5, wherein said plasma osmotic pressure measurement device comprises a means for measuring the electrolytic concentration of the plasma.
Claim 10
Independent Claim
24 words
An apparatus according to any one of claims 3 to 8, wherein said osmolal solution includes at least one electrolyte as an osmolal solute.
Claim 11
Independent Claim
46 words
An apparatus according to any one of claims 3 to 9, wherein said water removal quantity regulator comprises at least one of a means for producing a mechanical pressure across the semipermeable membrane and a means for infusing a replacement fluid into said extracorporeal circulation system.
Claim 12
Independent Claim
29 words
An apparatus according to any one of the preceding claims, wherein said circulating blood volume measuring instrument :.3 a hematocrit measuring instrument which detects changes in the circulating blood.
Claim 13
Independent Claim
55 words
An apparatus according to any one of the preceding claims, wherein said hematocrit measuring instrument comprises a resistivity measurement device for measuring the electrical resistivity of the blood in said extracorporeal circulation system, a temperature compensator for compensating the measured resistivity for temperature, and an arithmetic circuit for calculating the hematocrit from the electrical resistivity.
Claim 14
Independent Claim
67 words
An apparatus according to any one of the preceding claims, wherein the resistivity measurement device has a measurement cell including at least one pair of electrodes provided in an insulative pipe communicating with said extracorporeal circulation system at positions symmetrically opposed with respect to the axis of the insulative pipe and separated from each other by a prescribed distance in the axial direction of said insulative pipe.
Claim 15
Independent Claim
55 words
An apparatus according to any one of the preceding claims, wherein said resistivity measurement device is further provided with a measurement cell for measuring the electrical resistivity of the plasma component of the blood, and the hematocrit is calculated from both the electrical resistivity of the blood and the electrical resistivity of the plasma component.
Claim 16
Independent Claim
50 words
An apparatus according to any one of the preceding claims, wherein a filter is provided for ultrafiltrating a portion of the plasma from said extracorporeal circulation system and the measurement cell for measuring the electrical resistivity of the plasma component is provided in a waste filtrate path of said filter.
References Cited (Backward Citations)
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