EP0105053A1
Expired / Lapsed
EP
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Aralkylaminoethanol heterocyclic compounds
Assignee: Organon Pharma UK Ltd
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Filing: 1982-10-01
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Granted: —
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Expires: 2002-10-01
Abstract
Abstract Heterocyclic aminoethanols of the formula where het is a 6-10 membered N heterocycle are disclosec The compounds are useful as pharmaceuticals.
Inventors
- 👤 Joseph G. Atkinson
- 👤 John J. Baldwin
- 👤 David E. Mcclure
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 02:58
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; C07D213/61; C07D213/72; C07D213/73; C07D213/89; C07D263/00; C07D263/52; C07D263/54; C07D263/58; C07D265/00; C07D265/28; C07D265/34; C07D265/36; C07D405/00; C07D405/02; C07D405/04; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
92 words
Compounds of the formula: tautomers, pharmaceutically acceptable salts and individual enantiomers thereof wherein R 1 is H or OH Z is O or NH R is wherein R 3 is wherein R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl, Y is CH 2 , (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 or -CH 2 -O- R 6 is H, OH, OCH 3 , halogen, methylenedioxy or C 1 -C 3 alkyl and n is 1 or 2.
Claim 2
Dependent Claim
92 words
Compounds of the formula: tautomers, pharmaceutically acceptable salts and individual enantiomers thereof wherein R 1 is H or OH Z is O or NH R is wherein R 3 is wherein R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl, Y is CH 2 , (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 or -CH 2 -O- R 6 is H, OH, OCH 3 , halogen, methylenedioxy or C 1 -C 3 alkyl and n is 1 or 2.
Claim 3
Dependent Claim
32 words
-2. The compounds of Claim 1 formula (a) where R 1 is H, (b), (c), (d) where R 1 is H, (e), (f) where R 1 is H, (g) and (h) .
Claim 4
Dependent Claim
15 words
The compounds of Claim 2 wherein R 6 is H, OH or OCH 3 .
Claim 5
Dependent Claim
23 words
The compounds of Claim 3 wherein R 3 is wherein R 4 , and R 5 , are either CH 3 or H.
Claim 6
Dependent Claim
12 words
Compounds of Claim 2 having formula (a), (b), (c), (e) or (g).
Claim 7
Dependent Claim
8 words
Compounds of Claim 5 having the formula or
Claim 8
Dependent Claim
8 words
The compounds of Claim 5 having formula (c).
Claim 9
Dependent Claim
10 words
8 . The compounds of Claim 7 having the formula
Claim 10
Dependent Claim
10 words
9 . The compounds of Claim 5 having formula (g).
Claim 11
Dependent Claim
12 words
The compounds of Claim 5 having the formula or and tautomers thereof.
Claim 12
Dependent Claim
13 words
11 . The compound of Claim 10 having the' formula and its tautomers.
Claim 13
Dependent Claim
18 words
A compound of Claim 1 having the formula: or their maleate or HCl salts, individual enantiomers and tautomers,
Claim 14
Dependent Claim
9 words
Compounds (a), (c), (d) and (e) of Claim 12.
Claim 15
Dependent Claim
5 words
Compound (e) of Claim 12.
Claim 16
Dependent Claim
20 words
Pharmaceutical compositions for (a) reducing intraocular pressure (b) treating hypertension or (c) effecting bronchodilation containing a compound of Claim 1.
Claim 17
Dependent Claim
12 words
The S,S, S,R, R,S or R,R isomer of the Claim 11 compound.
Claim 18
Dependent Claim
14 words
Compounds of Claim 1 formula a) d) and f) where R 1 is OH.
Claim 19
Dependent Claim
23 words
1 8. Compounds of the formula wherein Het has the formula tautomers and individual isomers thereof, where R 1 is H or OH.
Claim 20
Dependent Claim
23 words
1 8. Compounds of the formula wherein Het has the formula tautomers and individual isomers thereof, where R 1 is H or OH.
References Cited (Backward Citations)
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