EP0107559B1
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Process for homogenising dispersions of hydrated lipidic lamellar phases
Assignee: Parfums Christian Dior SA
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Filing: 1983-10-06
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Granted: 1987-06-24
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Expires: 2003-10-06
Abstract
Abstract The invention concerns a method of homogenizing dispersions of hydrated lipidic lamellar phases and suspensions obtained thereby which can be applied particularly to the making of products intended for cosmetic, pharmaceutical and medical uses. The method consists in dispersing in a dispersion liquid a lipidic phase or a lipidic lamellar phase containing one or several amphiphilic lipids and then in homogenizing the said dispersion by feeding the same under a pressure comprised between 10,000 and 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element arranged in the section of the orifice adjustably, against the flow of the dispersion.
Inventors
- 👤 Gérard Redziniak
- 👤 Alain Meybeck
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 21:02
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; A61K8/00; A61K8/02; A61K8/14; A61K8/18; A61K8/96; A61K8/97; A61K8/9783; A61K8/9789; A61K8/9794; A61Q; A61Q19/00; B; B01; B01F; B01F25/00; B01F25/40; B01F25/44; B01F25/441; B01F25/4413; B01F25/442; B01F25/4422; B01F25/45; Y; Y10; Y10S; Y10S516/00; Y10S516/924; Y10S516/929; Y10S516/93; Y10S977/00; Y10S977/70; Y10S977/778; Y10S977/783; Y10S977/84; Y10S977/902; Y10S977/904; Y10S977/926; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
117 words
Method for obtaining a homogenized suspension of hydrated lipidic lamellar phases in a liquid such as a suspension of liposomes, consisting in dispersing a lipidic phase or a lipidic lamellar phase containing one or several amphiphile lipids such as lecithin and possibly one or several components of hydrophobic character into the said liquid and then in homogenizing the dispersion through an opening, characterized in that the said dispersion is fed into a passage-way of small width defined between the walls of the said opening and the edges of a shutter element adjustably disposed in the section of the said opening, in counterflow to the said dispersion, under a feed pressure lying between 10,000 kPa and 70,000 kPa.
Claim 2
Dependent Claim
117 words
Method for obtaining a homogenized suspension of hydrated lipidic lamellar phases in a liquid such as a suspension of liposomes, consisting in dispersing a lipidic phase or a lipidic lamellar phase containing one or several amphiphile lipids such as lecithin and possibly one or several components of hydrophobic character into the said liquid and then in homogenizing the dispersion through an opening, characterized in that the said dispersion is fed into a passage-way of small width defined between the walls of the said opening and the edges of a shutter element adjustably disposed in the section of the said opening, in counterflow to the said dispersion, under a feed pressure lying between 10,000 kPa and 70,000 kPa.
Claim 3
Dependent Claim
16 words
Method according to claim 1, characterized in thatthe feed pressure lies between 10,000 kPaand 40,000 kPa.
Claim 4
Dependent Claim
17 words
Method according to claim 1, characterized in that the aforesaid feed pressure is of about 30,000 kPa.
Claim 5
Dependent Claim
32 words
Method according to claim 1, 2 or 3, characterized in that the lipidic lamellar phase is anot very much hydrated lipidic lamellar phase having a lipidic phase content between 50% and 80%.
Claim 6
Dependent Claim
36 words
Method according to one of claims 1 to 4, characterized in that one carries out several successive passages of the dispersion within the aforesaid passage-way with possibly a cooling of the said dispersion between each passage.
Claim 7
Dependent Claim
49 words
Method according to one of the foregoing claims, characterized that the aforesaid dispersion contains from 50% to 99.9% of liquid and from 50 to 0.1 % of the lipidic phase or from 20 to 99.9% of liquid and from 80 to 0.1% of the aforesaid hydrated lipidic lamellar phase.
Claim 8
Dependent Claim
35 words
Method according to one of the foregoing claims, characterized in that the dispersion to be homogenized is pre-fed under pressure into a device performing the feeding under pressure of the dispersion into the aforesaid passage-way.
Claim 9
Dependent Claim
25 words
Method according to claim 7, characterized in that the said pre-feeding under pressure of the dispersion is carried out in an inert or non-oxidizing atmosphere.
Claim 10
Dependent Claim
29 words
Method according to one of the foregoing claims, characterized in that the aforesaid dispersion liquid is a solution of a product which is biologically active and/or has organoleptic properties.
Claim 11
Dependent Claim
28 words
Method according to one of claims 1 to 8, characterized in that the aforesaid liquid of the dispersion is an aqueous physiological solution of sodium chloride or d-glucose.
References Cited (Backward Citations)
No citation records indexed.
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