EP0140596A2
Expired / Lapsed
EP
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Protein/polysaccharide complexes
Assignee: Johnson and Johnson
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Filing: 1984-10-03
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Granted: —
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Expires: 2004-10-03
Abstract
Abstract @ Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such as sutures, blood vessel grafts, and artificial organs. The biodegradable protein is preferably collagen, and the polysaccharide is preferably sodium alginate. The complexes are preferably formed by combining the protein and the polysaccharide at a pH which is no higher than the isoelectric point of the protein. The complexes may be crosslinked, such as by dehydrothermal crosslinking or by the use of chemical crosslinking agents such as aldehydes or carbodiimides. Multivalent cations may also be incorporated in the complex in order to give added strength.
Inventors
- 👤 Ian Alexander Easton
- 👤 Stephen Dudley Gorham
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 08:22
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L17/00; A61L17/06; A61L17/08; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; C08B; C08B37/00; C08B37/006; C08B37/0084; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
42 words
A process for forming a protein/polysaccharide complex, said process comprising treating a biodegradable protein, or a hydrolytie degradation product thereof, with a polyanionic plant polysaccharide at a pM which is no higher than the isoelectric pH of said protein or degradation product.
Claim 2
Dependent Claim
42 words
A process for forming a protein/polysaccharide complex, said process comprising treating a biodegradable protein, or a hydrolytie degradation product thereof, with a polyanionic plant polysaccharide at a pM which is no higher than the isoelectric pH of said protein or degradation product.
Claim 3
Dependent Claim
12 words
A process according to claim 1, wherein the biodegradable protein is collagen.
Claim 4
Dependent Claim
15 words
A process according to claim 1 or claim 2, wherein the polysaccharide is an alginate.
Claim 5
Dependent Claim
26 words
A process according to any preceding claim wherein the complex is precipitated from a solution containing less than 2% w/v of protein or protein degradation product.
Claim 6
Dependent Claim
14 words
A process according to claim 4, wherein said solution contains less than 1% w/v.
Claim 7
Dependent Claim
14 words
A process according to claim 5, wherein said solution contains less than 0.5% w/v.
Claim 8
Dependent Claim
15 words
A process according to claim 6, wherein said solution contains from 0.3 to 0.35% w/v.
Claim 9
Dependent Claim
20 words
A process according to any preceding claim wherein the protein constitutes from 50 to 99% by weight of the complex.
Claim 10
Dependent Claim
21 words
' A process according to any preceding claim wherein the protein constitutes from 50 to 80% by zight of the complex.
Claim 11
Dependent Claim
14 words
A process according to any preceding alaim wherein the complex is dried by freeze-drying.
Claim 12
Dependent Claim
14 words
A process according to any preceding alaim wherein the complex is dried by freeze-drying.
Claim 13
Dependent Claim
17 words
A process according to claim 10 wherein said complex is blast frozen prior to said freeze-drying step.
Claim 14
Dependent Claim
18 words
A porous complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 15
Dependent Claim
18 words
A porous complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 16
Dependent Claim
11 words
A complex according to claim 12 wherein said protein is collagen.
Claim 17
Dependent Claim
15 words
A complex according to claim 12 or claim 13 wherein the polysuccharide is an alginate.
Claim 18
Dependent Claim
18 words
A complex according to any of claims 12 to 14 having a pore size greater than 20 microns.
Claim 19
Dependent Claim
14 words
A complex according to claim 15 having a pore size greater than 50 microns.
Claim 20
Dependent Claim
14 words
A complex according to claim 16 having a pore size greater than 100 microns.
Claim 21
Dependent Claim
27 words
A wound dressing having a wound contacting layer formed from a complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 22
Dependent Claim
27 words
A wound dressing having a wound contacting layer formed from a complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 23
Dependent Claim
20 words
A wound dressing having a wound contacting layer formed from a complex according to any of claims 12 to 17.
Claim 24
Dependent Claim
22 words
A surgical implant formed from a complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 25
Dependent Claim
22 words
A surgical implant formed from a complex of a biodegradable protein, or a proteolytic degradation product thereof, with a polyanionic plant polysaccharide.
Claim 26
Dependent Claim
12 words
A surgical implant according to claim 20 wherein said protein is collagen.
Claim 27
Dependent Claim
16 words
A surgical implant according to claim 20 or claim 21 wherein said polysaccharide is an alginate.
References Cited (Backward Citations)
No citation records indexed.
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