Patent US2982170A successfully refreshed from Google Patents.
EP0153828A2
Expired / Lapsed
EP
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1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acids; their derivatives and a process for preparing the compounds
Assignee: Warner Lambert Co LLC
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Filing: 1985-02-08
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Granted: —
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Expires: 2005-02-08
Abstract
Abstract Compounds of formula are disclosed. A process for producing the compounds and pharmaceutical compositions comprising the compounds are also described. The compounds are useful as antibacterial agents.
Inventors
- 👤 Thomas F. Mich
- 👤 Joseph P. Sanchez
- 👤 John M. Domagala
- 👤 Ashok K. Trehen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 09:04
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/74; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; C07D401/00; C07D401/02; C07D401/04; C07D407/00; C07D407/02; C07D407/12; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
11 words
CLAIMS (for BE, CH, DE, FR, GB, IT, LI,LU,NL, SE) :
Claim 2
Dependent Claim
65 words
A compound of the formula wherein Z is a group of the formula where n is 2-3 and R 2 is hydrogen, lower alkyl or acetyl, where Y is O or S, or where n' is 4-6 and R 3 is hydrogen or hydroxyl; X is CF, or N; R 1 is hydrogen or lower alkyl, or a pharmaceutically acceptable acid-addition or base salt thereof.
Claim 3
Dependent Claim
52 words
A compound of the formnla wherein Z is a group of the formula where Y is O or S, or where n' is 4-6 and R 3 is hydrogen or hydroxyl; X is CF, or N; R 1 is hydrogen or lower alkyl, or a pharmaceutically acceptable acid-addition or base salt thereof.
Claim 4
Dependent Claim
21 words
A pharmaceutical composition comprising a compound as claimed in Claim 1 or 2 together with a pharmaceutically acceptable carrier or diluent.
Claim 5
Dependent Claim
12 words
A compound according to Claim 2, having the name: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-hydroxy-l-pyrrolidinyl) -4-oxo-3-quinolinecarboxylic acid.
Claim 6
Dependent Claim
53 words
5 . A process for the preparation of a compound as claimed in claim 1 which comprises reacting a compound of the formula wherein L is fluorine or chlorine with an amine corresponding to group Z, and, if desired, converting the resulting product to a pharmaceutically acceptable acid addition or base salt thereof.
Claim 7
Dependent Claim
3 words
CLAIMS (for AT):
Claim 8
Dependent Claim
110 words
A process for the preparation of a compound of the formula wherein Z is a group of the formula where n is 2-3 and R 2 is hydrogen, lower alkyl or acetyl, where Y is O or S, or where n' is 4-6 and R 3 is hydrogen or hydrbxyl; X is CF, or N; R l is hydrogen or lower alkyl, or a pharmaceutically acceptable acid-addition or base salt thereof; which process comprises reacting a compound of the formula wherein L is fluorine or chlorine with an amine corresponding to group Z, and, if desired, converting the resulting product to a pharmaceutically acceptable acid addition or base salt thereof.
Claim 9
Dependent Claim
96 words
A process for the preparation of a compound of the formula wherein Z is a group of the formula where Y is O or S, or where n' is 4-6 and R 3 is hydrogen or hydroxyl; X is CF, or N; R 1 is hydrogen or lower alkyl, or a pharmaceutically acceptable acid-addition or base salt thereof; which comprises reacting a compound of the formula wherein L is fluorine or chlorine with an amine corresponding to group z, and, if desired, converting the resulting product to a pharmaceutically acceptable acid addition or base salt thereof.
Claim 10
Dependent Claim
30 words
A process for preparing a pharmaceutical composition which comprises combining a compound prepared by a process as claimed in any preceding claim together with a pharmaceutically acceptable carrier or diluent.
Claim 11
Dependent Claim
18 words
A process according to Claim 1 or 2, for preparing a compound having the name: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-hydroxy-1-pyrrolidinyl)-4-oxo-3-guinoline- carboxylic acid.
References Cited (Backward Citations)
No citation records indexed.
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