EP0159167A2
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EP
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Ointment base
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1985-04-04
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Granted: —
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Expires: 2005-04-04
Abstract
Abstract An ointment base for external use is provided which contains a water-soluble protein and monohydric alcohol or/and oleginous substance and additionally contains a wetting agent. The present ointment base offers a markedly improved percutaneous absorption of drugs, as compared with the conventional ointment bases.
Inventors
- 👤 Kazuo Kigasawa
- 👤 Hideaki Ohtani
- 👤 Makoto Tanaka
- 👤 Shigeru Hayashida
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 10:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/30; A61K47/42
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
32 words
An ointment base which comprises a water-soluble protein capable of producing a percutaneous absorption-promoting effect and a monohydric alcohol or/and an oleaginous substance as main components and additionally containing a wetting agent.
Claim 2
Dependent Claim
32 words
An ointment base which comprises a water-soluble protein capable of producing a percutaneous absorption-promoting effect and a monohydric alcohol or/and an oleaginous substance as main components and additionally containing a wetting agent.
Claim 3
Dependent Claim
28 words
An ointment base according to claim 1, wherein the amount of the water-soluble protein is 0.5 - 20 wt.%, based on the weight of the whole ointment base.
Claim 4
Dependent Claim
30 words
An ointment base according to claim 1 or 2, wherein the amount of the monohydric alcohol is 5 - 40 wt.%, based on the weight of the whole ointment base.
Claim 5
Dependent Claim
30 words
An ointment base according to claim 1 or 2, wherein the amount of the oleaginous substance is 0.5 - 25 wt.%, based on the weight of the whole ointment base.
Claim 6
Dependent Claim
15 words
An ointment base according to any one of the preceding claims, which also contains water.
Claim 7
Dependent Claim
47 words
An ointment base according to any one of the preceding claims, wherein the amount of the wetting agent is 2 - 30 wt.% when water is present or is 50 to 85 wt.% when water is not present, based on the weight of the whole ointment base.
Claim 8
Dependent Claim
18 words
An ointment base according to any one of the preceding claims, which contains a thickener and/or an emulsifier.
Claim 9
Dependent Claim
24 words
An ointment base according to any one of the preceding claims, wherein the water-soluble protein is selected from animal proteins, vegetable proteins and peptides.
Claim 10
Dependent Claim
23 words
An ointment base according to any one of the preceding claims, wherein the monohydric alcohol when present contains 2 - 4 carbon atoms.
Claim 11
Dependent Claim
34 words
An ointment base according to any one of the preceding claims, wherein the oleaginous substance when present is selected from fatty acid esters, aliphatic higher alcohols, paraffin oil, lanolin oil, silicone oil and Plastibase.
Claim 12
Dependent Claim
64 words
An ointment base according to claim 10, wherein the oleaginous substance is one to four selected from 1 esters of medium to higher fatty acids and aliphatic monools, triols or polyols having 4 - 8 hydroxyl groups containing 1 - 20 carbon atoms; Q2 aliphatic higher alcohols containing 14 - 20 carbon atoms; ③ liquid paraffin; ④ white petrolatum; ⑤ lanolin; and ⑥ silicone.
Claim 13
Dependent Claim
53 words
An ointment base according to claim 11, wherein the oleaginous substance is a triglyceride of a medium to higher fatty acid containing 6 to 20 carbon atoms, or an ester of a medium to higher fatty acid containing 6 to 20 carbon atoms and an aliphatic monool containing 1 to 20 carbon atoms.
Claim 14
Dependent Claim
25 words
An ointment base according to any one of the preceding claims, wherein the wetting agent is at least one glycol, triol, polyol or amino acid.
Claim 15
Dependent Claim
30 words
An ointment base according to any one of the preceding claims, wherein the wetting agent is an alkylene glycol containing 2 to 6 carbon atoms, polyethylene glycol, glycerin or sorbitol.
Claim 16
Dependent Claim
20 words
An ointment base according to any one of the preceding claims, which also contains a preservative and/or a pH-controlling agent.
Claim 17
Dependent Claim
22 words
Use of an ointment base as claimed in any one of the preceding claims in the formulation of drugs for percutaneous application.
References Cited (Backward Citations)
No citation records indexed.
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