EP0198769A2
Expired / Lapsed
EP
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Floating sustained release therapeutic compositions
Assignee: Forest Laboratories LLC
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Filing: 1986-04-10
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Granted: —
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Expires: 2006-04-10
Abstract
Abstract Sustained release tablets which will float on gastric juice are described. They comprise a hydrocolloid gelling agent such as agar, a therapeutically acceptable inert oil, the selected therapeutic agent and water.
Inventors
- 👤 Sanford Bolton
- 👤 Subhash Desai
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 21:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0065; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2022; A61K9/205
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
81 words
A therapeutic composition in dosage unit from as a non-compressed tablet having a density of less than one and capable of floating on gastric juice in vivo characterized in that it comprises a matrix formed from a gelling agent containing a therapeutic agent, a therapeutically acceptable inert oil and water in the following percentages by weight based on the total weight : gelling agent, 0.5 to 4 %; oil, 8 to 30 %; therapeutic agent 50 to 75 %; balance water.
Claim 2
Dependent Claim
81 words
A therapeutic composition in dosage unit from as a non-compressed tablet having a density of less than one and capable of floating on gastric juice in vivo characterized in that it comprises a matrix formed from a gelling agent containing a therapeutic agent, a therapeutically acceptable inert oil and water in the following percentages by weight based on the total weight : gelling agent, 0.5 to 4 %; oil, 8 to 30 %; therapeutic agent 50 to 75 %; balance water.
Claim 3
Dependent Claim
45 words
A therapeutic composition according to claim 1 comprising an agar matrix containing theophylline, mineral oil and water in the following percentages by weight based on the total weight; agar, 0.5 to 4 %; oil, 12 to 20 %; theophylline 50 to 75 %; balance water.
Claim 4
Dependent Claim
114 words
A method of forming a therepeutic composition according to claim 1 characterized in that it comprises : (1) forming a solution of a gelling agent in water, (2) forming a first mixture containing a therapeutic acceptable inert oil and a therapeutic agent, (3) cooling said solution, (4) combining the solution and mixtures to produce a second mixture containing from 0.5 to 2 % of the gelling agent, 8 to 30 % of the oil, 25 to 50% of the therapeutic agent, balance water, all by weight based on the total weight, (5) pouring the second mixture into a tablet mold and letting it stand in the mold to form a gel, and (6) drying.
Claim 5
Dependent Claim
105 words
A method of forming a therapeutic composition according to claim 2 characterized in that it comprises : (1) forming a solution containing agar in water, (2) forming a first mixture containing theophylline in mineral oil, (3) cooling said solution, (4) combining the solution and mixture to produce a second mixture containing from 0.5 to 2 % agar, 8 to 15 % of the oil and 25 to 50 % of the theophylline, balance water, all by weight based on the total weight, (5) pouring the second mixture into a tablet mold and letting it stand in the mold to form a gel, and (6) drying.
References Cited (Backward Citations)
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