Patent US2820457A successfully refreshed from Google Patents.
EP0210875A2
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EP
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Apparatus for delivering insoluble material into a living body and method of use thereof
Assignee: Theragenics Corp
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Filing: 1986-08-01
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Granted: —
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Expires: 2006-08-01
Abstract
Abstract To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials (12), and a system is provided forflushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.
Inventors
- 👤 John Lynn Russell, Jr.
- 👤 John Lewis Carden, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 03:36
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/1414; A61M5/007; A61M2005/1401; A61M2005/1403; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N2005/1019; A61N2005/1021; A61N5/1007; Y; Y10; Y10S; Y10S604/00; Y10S604/903
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
255 words
A system for delivering a controlled amount of solid insoluble particulates containing a ratioactive isotope into a living body which comprises: one or more vials, each having a known amount of said particulates and a determinable radiation dosage, the radiation dosage to be administered being substantially the total dosage from the vial, if one, or the sum of substantially the total dosages from all of a selected number of the vials, if more than one; a source of liquid compatible with internal administration into the body of the mammal; means for accessing an internal region of the body; first means for conducting liquid from said source to said vial, or, simultaneously or successively, said selected number of vials; second means for conducting liquid from said vial or selected number of vials to said means for accessing; and pumping means for delivery of liquid from said source through said vial or selected number of vials and to said means for accessing with a flow velocity sufficient to flush the particulates from said vial or selected number of vials to the body of the mammal; provided that, during passage of liquid from said source through a vial to flush the particulates from the vial, the vial has an inlet means positioned to have an opening, through which said liquid passes into the vial, near the lowermost region of the vial and an outlet means positioned to have an opening, through which said liquid entraining particulates passes into the outlet means, above said opening of said inlet means.
Claim 2
Independent Claim
255 words
A system for delivering a controlled amount of solid insoluble particulates containing a ratioactive isotope into a living body which comprises: one or more vials, each having a known amount of said particulates and a determinable radiation dosage, the radiation dosage to be administered being substantially the total dosage from the vial, if one, or the sum of substantially the total dosages from all of a selected number of the vials, if more than one; a source of liquid compatible with internal administration into the body of the mammal; means for accessing an internal region of the body; first means for conducting liquid from said source to said vial, or, simultaneously or successively, said selected number of vials; second means for conducting liquid from said vial or selected number of vials to said means for accessing; and pumping means for delivery of liquid from said source through said vial or selected number of vials and to said means for accessing with a flow velocity sufficient to flush the particulates from said vial or selected number of vials to the body of the mammal; provided that, during passage of liquid from said source through a vial to flush the particulates from the vial, the vial has an inlet means positioned to have an opening, through which said liquid passes into the vial, near the lowermost region of the vial and an outlet means positioned to have an opening, through which said liquid entraining particulates passes into the outlet means, above said opening of said inlet means.
Claim 3
Dependent Claim
24 words
A system as claimed in claim 1 which further comprises means for venting air prior to pumping liquid with entrained particulates into the body.
Claim 4
Dependent Claim
55 words
A system as claimed in claim 1 or claim 2 wherein the interior of the vial or vials is substantially free of edges or corners whereat the insoluble particulates may reside and has a bottom surface which declines smoothly and continuously to a lowermost region, whereat particulates tend to accumulate under the force of gravity.
Claim 5
Independent Claim
39 words
A system as claimed in any one of claims 1 to 3 wherein the ratio of the density of the particulates to the density of the liquid compatible with internal administation into the body is between 1.5 and 3.5.
Claim 6
Independent Claim
52 words
A system as claimed in any one of the preceding claims wherein in flushing particulates from each vial, a volume of liquid between 50 and 400 times the volume of particulates in the vial prior to the flushing removes at least 75 percent of the particulates from the vial into the body.
Claim 7
Independent Claim
32 words
A system as claimed in any one of the preceding claims wherein the ratio of the volume of particulates in each vial to the volume of the vial is less than 0.2.
Claim 8
Independent Claim
107 words
A system as claimed in any one of the preceding claims wherein every vial is sealed with a self-sealing septum; wherein the inlet means and the outlet means of a vial during passage of liquid therethrough are hollow needles inserted through said septum of the vial; and wherein the pumping means comprises a syringe having a barrel and a piston slidable within said barrel and valving means for directing the flow of liquid from the source of liquid into said barrel when said piston is withdrawn within said barrel through the first conducting means to the vial or vials when said piston is plunged into said barrel.
Claim 9
Independent Claim
18 words
A system as claimed in any one of the preceding claims wherein the number of vials is one.
Claim 10
Independent Claim
66 words
A system as claimed in any one of claims 1 to 7 wherein the number of vials is z+1, where z is at least 1, preferably 3, and wherein, prior to flushing of particulates from any of the vials, at least one of the vials contains a first amount of particulates and all of the vials contain an integral multiple of said first amount of particulates.
Claim 11
Dependent Claim
54 words
A system as claimed in claim 9 wherein, prior to flushing of particulates from any of the vials, each of the vials contains a different amount of particulates and contains an amount of particulates equal to 2 n times said first amount of particulates, where n is an integer between 0 and z, inclusive.
Claim 12
Independent Claim
25 words
A system as claimed in any one of the preceding claims wherein radiation shielding material is disposed in shielding relationship to the vial or vials.
Claim 13
Dependent Claim
86 words
A method as claimed in claim 11 which further comprises ascertaining the dosage of radioactivity to be delivered to the body; evaluating the radioactivity in each of the vials at about the time of delivery of the particulates into the body; based on said evaluation of radioactivity, selecting the number of vials in the system which together contain the amount of radioactivity which is nearest the dosage to be delivered; and delivering substantially all of the particulates from said selected number of vials into said body.
Claim 14
Independent Claim
82 words
A system for delivering a controlled amount of an insoluble material into a living body which comprises at least one vial having an inlet and an outlet and containing a measured amount of said insoluble material, a fluid source connecting with said vial, means for fluid communication between said vial and the living body, and means for pumping fluid from said source through the vial so as to flush substantially the entire amount of insoluble material from the vial into the body.
Claim 15
Independent Claim
82 words
A system for delivering a controlled amount of an insoluble material into a living body which comprises at least one vial having an inlet and an outlet and containing a measured amount of said insoluble material, a fluid source connecting with said vial, means for fluid communication between said vial and the living body, and means for pumping fluid from said source through the vial so as to flush substantially the entire amount of insoluble material from the vial into the body.
Claim 16
Independent Claim
44 words
A system for delivering a controlled amount of an insoluble material into a living body which comprises flushing means adapted using a source of fluid to flush said controlled amount of material from a container therefor through a fluid communication means to the body.
Claim 17
Independent Claim
44 words
A system for delivering a controlled amount of an insoluble material into a living body which comprises flushing means adapted using a source of fluid to flush said controlled amount of material from a container therefor through a fluid communication means to the body.
Claim 18
Dependent Claim
22 words
The use of a fluid to flush a controlled amount of an insoluble material from a container therefor into a living body.
Claim 19
Dependent Claim
22 words
The use of a fluid to flush a controlled amount of an insoluble material from a container therefor into a living body.
References Cited (Backward Citations)
No citation records indexed.
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