EP0214614A2
Expired / Lapsed
EP
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Non-lytic sheath composition
Assignee: Bayer Corp
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Filing: 1986-09-03
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Granted: —
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Expires: 2006-09-03
Abstract
Abstract This invention relates to a novel non-lytic sheath composition for use in inhibiting the retention of bubbles in high-speed automated biomedical analytical systems, The sheath composition comprises an aqueous solution of, in admixture, a buffer, an osmolality filler and a nonionic surfactant wherein said surfactant is a polymer of polyols having terminal hydroxyl groups.
Inventors
- 👤 Syed I. Ahmad
- 👤 Jeffrey Benezra
- 👤 Michael J. Malin
- 👤 Shambu Prasad
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 14:20
CPC Classifications
G; G01; G01N; G01N15/00; G01N15/10; G01N15/14; G01N15/1404; G01N15/1409
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
36 words
A non-lytic sheath composition comprising an aqueous solution of, in admixture, a) a buffer, b) an osmolality filler; and c) a non-ionic surfactant, wherein said surfactant is a copolymer of polyols terminating in primary hydroxyl groups.
Claim 2
Dependent Claim
36 words
A non-lytic sheath composition comprising an aqueous solution of, in admixture, a) a buffer, b) an osmolality filler; and c) a non-ionic surfactant, wherein said surfactant is a copolymer of polyols terminating in primary hydroxyl groups.
Claim 3
Dependent Claim
31 words
The sheath composition of claim 1 wherein the surfactant has the formula HO-CH₂CH₂-O-[(CH₂CH₂-O) n -(CH₂CH₂CH₂-O) m ]-CH₂CH₂CH-OH wherein n and m are, same or different, from about 39 to about 77.
Claim 4
Dependent Claim
16 words
The sheath composition of claim 2 wherein n is about 72 and m is about 56.
Claim 5
Dependent Claim
19 words
The sheath composition of claim 1 wherein the surfactant is a block copolymer of propylene oxide and ethylene oxide.
Claim 6
Dependent Claim
19 words
The sheath composition of any claims 1 to 4 wherein the buffer is a mixture of NaH₂PO₄ and Na₂HPO₄.
Claim 7
Dependent Claim
19 words
The sheath composition of any of claims 1 to 5 wherein the osmolality filler is an alkali metal salt.
Claim 8
Dependent Claim
11 words
The sheath composition of claim 6 wherein the salt is NaCl.
Claim 9
Dependent Claim
60 words
The sheath composition of any of claims 1 to 7 wherein the buffer is present in an amount of from about 10 mM to about 30 mM, the osmolality filler is present in an amount of from about 108 mM to about 139 mM, and/or the surfactant is present in an amount of from about 0.7 g/L to 1.3 g/L.
Claim 10
Dependent Claim
57 words
The sheath composition of claim 8 wherein the buffer is present in an amount of from about 15 mM to about 25 mM, the osmolality filler is present in an amount of from about 114 mM to about 134 mM, and/or the surfactant is present in an amount of from about 0.9 g/L to about 1.1 g/L.
Claim 11
Dependent Claim
18 words
The sheath composition of any of claims 1 to 9 which contains an antioxidant and/or an antimicrobial agent.
Claim 12
Dependent Claim
20 words
The sheath composition of claim 10 wherein the antioxidant contains a preventative antioxidant, a chain-terminating antioxidant or mixtures of each.
Claim 13
Dependent Claim
19 words
The sheath composition of claim 11 wherein the preventative antioxidant is 3,3,'-thiodipropionic acid and the chain-terminating antioxidant is paramethoxyphenol.
Claim 14
Dependent Claim
17 words
The sheath composition of claim 11 wherein the anti-microbial agent is a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.
Claim 15
Dependent Claim
45 words
The sheath composition of any of claims 10 to 13 wherein the antimicrobial agent is present in an amount of from about 0.3 g/L to about 0.4 g/L and/or the antioxidant is present in an amount of from about 75 mg/L to about 300 mg/L.
Claim 16
Dependent Claim
37 words
The sheath composition of any of claims 1 to 14 wherein the pH of the composition is from about 7.0 to about 7.5, and the refractive index of the composition is from about 1.334 to about 1.335.
Claim 17
Dependent Claim
24 words
The sheath composition of any of claims 1 to 15 wherein the osmolality of the composition is from about 285 to about 305 mOsm/kg.
References Cited (Backward Citations)
No citation records indexed.
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