Patent US3547767A successfully refreshed from Google Patents.
EP0220907A2
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EP
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Process for the preparation of 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-galactopyranoside
Assignee: Janssen Pharmaceuticals Inc
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Filing: 1986-10-20
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Granted: —
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Expires: 2006-10-20
Abstract
Abstract A process for the preparation of 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-galactopyranoside comprising the steps of (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product; (c) detritylating the acetylated reaction product; (d) isomerizing the resulting penta-acetate; (e) chlorinating the isomerized product; and (f) deacetylating the chlorinated reaction product.
Inventors
- 👤 William Tully
- 👤 Nicholas M. Vernon
- 👤 Peter A. Walsh
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 02:27
CPC Classifications
A; A23; A23L; A23L27/00; C; C07; C07H; C07H5/00; C07H5/02; C07H13/00; C07H13/02; C07H13/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
18 words
A process for the preparation of 2,3,6,3',4'-penta-O-acetylsucrose comprising isomerizing 2,3,4,3',4'-penta-O-acetylsucrose in a non-aqueous solvent with a weak base.
Claim 2
Dependent Claim
18 words
A process for the preparation of 2,3,6,3',4'-penta-O-acetylsucrose comprising isomerizing 2,3,4,3',4'-penta-O-acetylsucrose in a non-aqueous solvent with a weak base.
Claim 3
Dependent Claim
28 words
A process according to Claim 1 wherein the weak base is selected from the group consisting of tert-butylamine, triethylamine, pyrrolidine, di-N-propylamine, di-isopropylamine, morpholine, n-butylamine, isopropylamine, piperidine and diethylamine.
Claim 4
Dependent Claim
12 words
A process according to Claim 2 wherein the weak base is tert-butylamine.
Claim 5
Dependent Claim
23 words
A process according to any one of claims 1 to 3 which is carried out at a temperature of from 30°C to 60°C.
Claim 6
Dependent Claim
73 words
A process for the preparation of 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-galactopyranoside comprising the steps of: (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product with an acetylating agent to obtain 6,1',6'-tri-O-tritylsucrose penta-acetate; (c) detritylating the 6,1',6'-tri-O-tritylsucrose penta-acetate to obtain 2,3,4,3',4'-penta-O-acetylsucrose; (d) isomerizing the 2,3,4,3',4'penta-O-acetyl sucrose using a process according to any one of claims 1 to 4 to obtain 2,3,6,3',4'-penta-O-acetylsucrose; (e) chlorinating 2,3,6,3',4'-penta-O-acetylsucrose to obtain 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose pentaacetate; and (f) deacetylating the chlorinated product.
Claim 7
Dependent Claim
16 words
A process according to claim 5 wherein the tritylating agent in step (a) is trityl chloride.
Claim 8
Dependent Claim
19 words
A process according to claim 5 or claim 6 wherein the acetylating agent in step (b) is acetic anhydride.
References Cited (Backward Citations)
No citation records indexed.
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