EP0243145A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Topical antimicrobial pharmaceutical compositions
Assignee: Kabara Jon Joseph
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Filing: 1987-04-21
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Granted: —
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Expires: 2007-04-21
Abstract
Abstract The present invention discloses a topical antimicrobial pharmaceutical composition comprising an ethoxylated or propoxylated glyceryl fatty acid ester and a pharmaceutically acceptable carrier, the composition also optionally comprising a mixture of fatty acids including a first C6-18fatty acid antimicrobial agent and a second C6-18fatty acid antimicrobial agent; the compositions may also comprise a glyceryl fatty acid and a mixture of fatty acids; the compositions are useful in treating and preventing microbial-related skin conditions in humans or animals by topical application.
Inventors
- 👤 Jon Joseph Kabara
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 22:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A01; A01N; A01N37/00; A01N37/12; A61K31/185; A61K31/19; A61K31/20; A61K31/25; A61P; A61P17/00; A61P31/00; A61P31/04; A61P31/12
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
30 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) an ethoxylated or propoxylated glyceryl fatty acid ester, and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
30 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) an ethoxylated or propoxylated glyceryl fatty acid ester, and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
61 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) a glyceryl fatty acid ester; (b) a mixture of fatty acids comprising: (i) a first fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (ii) a second fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (c) a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
61 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) a glyceryl fatty acid ester; (b) a mixture of fatty acids comprising: (i) a first fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (ii) a second fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (c) a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
76 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) an ethoxylated or propoxylated glyceryl fatty acid ester; (b) a fatty acid mixture comprising: (i) a first fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (ii) a second fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid wherein the second fatty acid is not the same as the first fatty acid; and (c) a pharmaceutically-acceptable carrier.
Claim 6
Dependent Claim
76 words
A process for the preparation of a topical antimicrobial pharmaceutical composition which comprises mixing together: (a) an ethoxylated or propoxylated glyceryl fatty acid ester; (b) a fatty acid mixture comprising: (i) a first fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid; and (ii) a second fatty acid antimicrobial agent which is a C₆-C₁₈ fatty acid wherein the second fatty acid is not the same as the first fatty acid; and (c) a pharmaceutically-acceptable carrier.
Claim 7
Dependent Claim
29 words
A process according to claim 1 or 3 in which the glyceryl ester comprises at least 1 mole of ethoxy or propoxy moiety per 4 moles of glyceryl ester.
Claim 8
Dependent Claim
23 words
A process according to claim 4 wherein 0.5 to 5 moles of ethoxy or propoxy moiety are present per mole of glyceryl ester.
Claim 9
Dependent Claim
20 words
A process according to any one of claims 1 to 5 wherein the glyceryl fatty acid ester is a monoester.
Claim 10
Dependent Claim
15 words
A process according to claim 6 wherein the monoester contains 6 to 21 carbon atoms.
Claim 11
Dependent Claim
22 words
A process according to claim 7 wherein the monoester is monocaprylin, monocaprin, monolaurin, monomyristin, monopalmitolein, monolein, monoicosenoin, monoerucin or a mixture thereof.
Claim 12
Dependent Claim
28 words
A process according to any one of claims 6 to 8 wherein the monoester is present in an amount of 0.025 to 20.0% by weight of the composition.
Claim 13
Dependent Claim
31 words
A process according to any one of claims 2 to 9 wherein the ratio by weight of the ester to the first and second fatty acids combined is 1:10 to 10:1.
Claim 14
Dependent Claim
34 words
A process according to any one of claims 2 to 10 wherein the first fatty acid and/or the second fatty acid is a straight chain fatty acid having from six to twelve carbon atoms
Claim 15
Dependent Claim
28 words
A process according to any one of claims 1 to 11 in which the carrier used comprises an alcohol, chelating agent, surfactant, paraben, water, or a mixture thereof.
Claim 16
Dependent Claim
76 words
A process according to claim 10 wherein the pharmaceutical carrier comprises an alcohol which is propylene glycol, phenoxyethanol, methanol, ethanol, isopropyl alcohol, or a mixture thereof; a chelating agent which is EDTA, Na₂ (EDTA), Na₄ (EDTA), TEA, lactic acid, citric acid or a mixture thereof; a surfactant which is a sarcosinate, an amine oxide, pluronic 68, sodium lauryl sulfate or a mixture thereof; or a paraben which is methyl paraben, propyl paraben or a mixture thereof.
Claim 17
Dependent Claim
70 words
A process according to claim 10 or 11 wherein the alcohol is used in an amount of 5 percent to 60 percent by volume; the surfactant is used in an amount of 0.25 percent to 10 percent by weight; the paraben is used in an amount of 0.05 percent to 5 percent by weight; the chelating agent is used in an amount of 0.05 percent to 4 percent by weight.
Claim 18
Dependent Claim
19 words
A composition as defined in any one of claims 1 to 17 for use as a topical antimicrobial agent.
Claim 19
Dependent Claim
22 words
Use of a composition as defined in any one of claims 1 to 15 in the preparation of a topical antimicrobial medicament.
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