EP0243744A2
Expired / Lapsed
EP
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Red blood cell filtering system
Assignee: Bayer Corp
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Filing: 1987-04-08
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Granted: —
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Expires: 2007-04-08
Abstract
Abstract Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
Inventors
- 👤 Raleigh A. Carmen
- 👤 Chiyong Chong
- 👤 Barry S. Leng
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 08:03
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/02; A61M1/0209; A61M1/0218; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
94 words
Closed multiple blood bag system comprising at least two flexible plastic bags in closed communication with each other via connecting plastic tubing, characterized in that a filter is disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing containing continuous filtering fiber, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relatively high flow rate.
Claim 2
Dependent Claim
94 words
Closed multiple blood bag system comprising at least two flexible plastic bags in closed communication with each other via connecting plastic tubing, characterized in that a filter is disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing containing continuous filtering fiber, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relatively high flow rate.
Claim 3
Dependent Claim
20 words
The system of claim 1 wherein the continuous filtering fiber has a fiber length of greater than about 1000 meters.
Claim 4
Dependent Claim
20 words
The system of claim 1 wherein the filtering fiber has a density of less than about 0.6 grams per cc.
Claim 5
Dependent Claim
33 words
The system of claim 1 wherein the filter housing has a volume of less than about 50 cc and the filtering fiber has a generally Y-shaped cross sectional area and is cellulose acetate.
Claim 6
Dependent Claim
34 words
The system of claim 1 wherein the filter is capable of filtering a unit of blood comprising a mixture of red and white blood cells in less than about 3 hours at room temperature.
Claim 7
Dependent Claim
23 words
The system of claim 1 wherein the filter is capable of removing at least about 80% of white blood cells from the mixture.
Claim 8
Dependent Claim
44 words
The system of claim 6 wherein the filter is capable of filtering the cells and reducing long term hemolysis of the cells such that the amount of hemolysis detectable after five weeks storage of the filtered red blood cells is less than about 0.30%.
Claim 9
Dependent Claim
14 words
The system of claim 1 wherein the filter housing is tapered in one direction.
Claim 10
Dependent Claim
43 words
The system of claim 1 wherein the filter housing includes between the red blood cell exit and the contained filter fiber, at least two filter fiber support screens, the screen closer to the fiber having a mesh size larger than the remaining screen.
Claim 11
Dependent Claim
27 words
The system of claim 9 wherein the screens are fused to form an integral unit adapted to restrain the filter fiber without substantial clogging of the filter.
Claim 12
Dependent Claim
111 words
A closed multiple blood bag system comprising a first and second flexible bag in communication with each other via flexible tubing, the system including a red blood cell additive solution in the first bag and an in line filter in communication with the tubing and between the two bags, the filter comprising a housing having a volume of less than about 50 cc and containing continuous filtering fiber having a density of less than about 0.6 grams per cc, the fiber being retained with in the housing by a pair of fused support screens having different mesh sizes and disposed between the filter fiber and the RBC exit of the filter.
Claim 13
Dependent Claim
111 words
A closed multiple blood bag system comprising a first and second flexible bag in communication with each other via flexible tubing, the system including a red blood cell additive solution in the first bag and an in line filter in communication with the tubing and between the two bags, the filter comprising a housing having a volume of less than about 50 cc and containing continuous filtering fiber having a density of less than about 0.6 grams per cc, the fiber being retained with in the housing by a pair of fused support screens having different mesh sizes and disposed between the filter fiber and the RBC exit of the filter.
Claim 14
Independent Claim
207 words
A method of processing whole blood for the storage of red blood cells comprising the steps of - (a) collecting whole blood from a donor into the donor bag of a closed multiple blood bag system comprising a donor bag in communication with at least one other bag via connecting tubing, the tubing including an integral white blood cell filter and the other bag including a red blood cell additive solution; (b) centrifuging the whole blood in the donor bag under conditions sufficient to separate the whole blood into an upper plasma component and a lower red blood cell component which includes some white blood cells;' (c) removing the plasma component from the donor bag; _ (d) introducing the additive solution into the donor bag by passing it through the filter to prime the filter removing air from it and then mixing the solution with the red and white blood cells; and (e) passing the mixture of step (d) through the filter and into the other bag under conditions sufficient to remove substantially all white blood cells from the mixture, thereby providing a red blood cell preparation substantially free of white blood cells and suitable for long term storage without substantial amounts of white blood cell contaminants.
Claim 15
Independent Claim
207 words
A method of processing whole blood for the storage of red blood cells comprising the steps of - (a) collecting whole blood from a donor into the donor bag of a closed multiple blood bag system comprising a donor bag in communication with at least one other bag via connecting tubing, the tubing including an integral white blood cell filter and the other bag including a red blood cell additive solution; (b) centrifuging the whole blood in the donor bag under conditions sufficient to separate the whole blood into an upper plasma component and a lower red blood cell component which includes some white blood cells;' (c) removing the plasma component from the donor bag; _ (d) introducing the additive solution into the donor bag by passing it through the filter to prime the filter removing air from it and then mixing the solution with the red and white blood cells; and (e) passing the mixture of step (d) through the filter and into the other bag under conditions sufficient to remove substantially all white blood cells from the mixture, thereby providing a red blood cell preparation substantially free of white blood cells and suitable for long term storage without substantial amounts of white blood cell contaminants.
Claim 16
Dependent Claim
18 words
The method of claim 12 where steps (a) through (e) are accomplished within 24 hours of each other.
Claim 17
Dependent Claim
18 words
The method of claim 13 wherein steps (a) through (e) are accomplished within 6 hours of each other.
Claim 18
Dependent Claim
28 words
The method of claim 12 wherein the white blood cell filter includes filtering fiber of cellulose acetate having a density of less than about 0.6 grams per cc.
Claim 19
Dependent Claim
23 words
The method of claim 15 wherein the fiber is a continuous filtering fiber having a fiber length of greater than about 1000 meters.
Claim 20
Dependent Claim
18 words
The method of claim 15 wherein the filter housing has a volume of less than about 50 cc.
Claim 21
Dependent Claim
33 words
The method of claim 15 wherein the filter is capable of filtering a unit of blood comprising a mixture of red and white blood cells in less than about 3 hours at room'temperature.
Claim 22
Dependent Claim
23 words
The method of claim 15 wherein the filter is capable of removing at least about 80% of white blood cells from the mixture.
Claim 23
Dependent Claim
44 words
The method of claim 12 wherein the filter is capable of filtering the cells and reducing long term hemolysis of the cells such that the amount of hemolysis detectable after five weeks storage of the filtered red blood cells is less than about 0.30%.
References Cited (Backward Citations)
No citation records indexed.
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