EP0258780A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Polyesters containing alkylene oxide blocks as drug delivery systems
Assignee: Wyeth Holdings LLC
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Filing: 1987-08-25
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Granted: —
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Expires: 2007-08-25
Abstract
Abstract The invention is an ABA or AB block copolymer as a well as slow release drug delivery system comprising a drug and the ABA or AB block copolymer wherein one block (B) is a poly (alkylene oxide) and the other blocks (A) are comprised of degradable random copolymers of (1) the cyclic ester of an alpha-hydroxy acid and (2) a second cyclic ester monomer with the proviso that the second cyclic ester monomer is not the same as the first cyclic ester.
Inventors
- 👤 Donald James Casey
- 👤 Louis Rosati
- 👤 Peter Kendrick Jarrett
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 11:11
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/64; A; A61; A61K; A61K9/00; A61K9/70; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
25 words
A diblock copolymer having a first block comprising a polyalkylene oxide and a second block consisting essentially of glycolic acid ester and trimethylene carbonate linkages.
Claim 2
Dependent Claim
25 words
A diblock copolymer having a first block comprising a polyalkylene oxide and a second block consisting essentially of glycolic acid ester and trimethylene carbonate linkages.
Claim 3
Dependent Claim
22 words
A diblock copolymer of Claim 1 wherein the polyalkylene oxide block is from 5 to 25 percent by weight of the copolymer.
Claim 4
Dependent Claim
25 words
A diblock copolymer of Claim 1 or 2 wherein the number average molecular weight of the polyalkylene oxide block is from about 4,000 to 30,000.
Claim 5
Dependent Claim
64 words
A diblock copolymer of Claim 4 wherein the polyalkylene oxide block is derived from a block or random copolymer of a first cyclic ether selected from the group consisting of wherein x is 2 to about 9, and a second cyclic ether selected from the group consisting of wherein y is 1 to about 9 and R is a C₁ to C₆ alkyl group.
Claim 6
Dependent Claim
39 words
A triblock copolymer useful in non-fiber form having a middle block obtained by removing both terminal hydroxyl hydrogens from either a homopolymer of ethylene oxide, or from a block or random copolymer of ethylene oxide and a cyclic ether.
Claim 7
Dependent Claim
39 words
A triblock copolymer useful in non-fiber form having a middle block obtained by removing both terminal hydroxyl hydrogens from either a homopolymer of ethylene oxide, or from a block or random copolymer of ethylene oxide and a cyclic ether.
Claim 8
Dependent Claim
68 words
A slow release drug delivery system comprising a drug and an ABA or AB block polymer wherein the (B) block is a poly(alkylene oxide) and the blocks (A) are comprised of degradable random copolymers of (1) the cyclic ester of an alpha-hydroxy acid and (2) a second cyclic ester monomer with the proviso that the second cyclic ester monomer is not the same as the first cyclic ester.
Claim 9
Dependent Claim
68 words
A slow release drug delivery system comprising a drug and an ABA or AB block polymer wherein the (B) block is a poly(alkylene oxide) and the blocks (A) are comprised of degradable random copolymers of (1) the cyclic ester of an alpha-hydroxy acid and (2) a second cyclic ester monomer with the proviso that the second cyclic ester monomer is not the same as the first cyclic ester.
Claim 10
Dependent Claim
32 words
A drug delivery system according to Claim 6 wherein the polymer is a ABA block polymer, and the first cyclic ester is glycolide and the second cyclic ester monomer is trimethylene carbonate.
Claim 11
Dependent Claim
19 words
A drug deliver system according to Claim 7 wherein the B block is polyethylene oxide or polyethylene oxide-co-propylene oxide.
Claim 12
Dependent Claim
48 words
A drug delivery system according to Claim 7 wherein the drug is bovine somatotropin or theophylline and the poly(ethylene oxide) comprises from about 4 to about 54 weight % of the ABA polymer and the average molecular weight of the poly(ethylene oxide) is within a range of 6,000-25,000.
Claim 13
Dependent Claim
32 words
A drug delivery system according to Claim 6 wherein the polymer is an AB block polymer and the first cyclic ester is glycolide and the second cyclic ester monomer is trimethylene carbonate.
References Cited (Backward Citations)
No citation records indexed.
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