Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
61 words
A conjugate of the formula Ig-L-Gp or Re*-L-Gp wherein Ig represents an immunoglobulin or an immunologically reactive portion thereof, wherein Re* represents a receptor ligand, wherein Gp represents a hydro-monobenzoporphyrin having a light absorption maximum in the range of 670-720 nanometer, and wherein L represents a covalent bond or a linker moiety bound to the Ig and Gp through covalent bonds.
Claim 2
Dependent Claim
61 words
A conjugate of the formula Ig-L-Gp or Re*-L-Gp wherein Ig represents an immunoglobulin or an immunologically reactive portion thereof, wherein Re* represents a receptor ligand, wherein Gp represents a hydro-monobenzoporphyrin having a light absorption maximum in the range of 670-720 nanometer, and wherein L represents a covalent bond or a linker moiety bound to the Ig and Gp through covalent bonds.
Claim 3
Dependent Claim
26 words
The conjugate of claim 1 wherein the Ig is obtained from a preparation of monoclonal antibodies selected from CAMAL-1 and B16G and Re* is a hormone.
Claim 4
Dependent Claim
44 words
The conjugate of claim 1 or 2 wherein the Gp is selected from the group consisting of wherein each R³ is independently 2-carboxy ethyl or a derivative thereof, and wherein each R¹ and R² is independently an electron withdrawing substituent which is not cyano.
Claim 5
Dependent Claim
39 words
The conjugate of claim 3 wherein each R¹ and R² is independently selected from the group consisting of carboxy, carbalkoxy(1-6C), alkyl(1-6C) sulfonate, alkyl(1-6C) sulfone, and aryl, and wherein each R¹ and R² is optionally conjugated to a linker moiety.
Claim 6
Dependent Claim
15 words
The conjugate of any one of the preceding claims wherein L represents a covalent bond.
Claim 7
Dependent Claim
35 words
A pharmaceutical composition which is cytotoxic to specific cells or tissues which comprises an effective amount of the conjugate of any one of the preceding claims in admixture with at least one pharmaceutically acceptable excipient.
Claim 8
Dependent Claim
45 words
The conjugate of claim 3 for use in a method of treating the human or animal body, together with irradiation of the cells or tissues contacted with said conjugate with light in the wavelength range 670-720 nm, for the destruction of targeted cells or tissues.
Claim 9
Dependent Claim
31 words
The conjugate of claim 7 wherein each R¹ and R² is selected from the group consisting of carboxy, carbalkoxy(1-6C), alkyl(1-6C) sulfonate, alkyl(1-6C) sulfone, and aryl, optionally conjugated to a linker moiety.