Adhesive dressings containing a pharmaceutically active ingredient

Claim 2

An adhesive dressing containing a pharmaceutically active ingredient comprising a flexible backing member laminated to one surface of a pressure sensitive adhesive layer and a pharmaceutically active ingredient at the skin contacting surface and the adjacent strata of the adhesive layer said pressure sensitive adhesive layer comprising a homogeneous mixture of one or more polyisobutylenes or one or more polyisobutyl­enes and one or more elastomers, one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, and various optional ingredients.

Claim 3

An adhesive dressing of Claim 1 wherein said adhesive layer prior to incorporation of the pharmaceutcally active ingredient comprises from about 15% to about 50% by weight of one or more low molecular weight polyisobutylenes or blends of one or more low molecular weight polyisobutylenes and one or more elastomers, from about 20% to about 70% by weight of one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, up to about 25% by weight of mineral oil, and up to about 20% by weight of tackifiers, wherein said elastomer if present is selected from the group consisting of butyl rubber, medium and high molecular weight polyiso­butylenes, and styrene radial or block copolymers, said moisture absorbing, moisture transmitting, water soluble agents are selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, xanthan gum, mixed sodium/calcium salts of alginic acid, and carrageenan said moisture absorbing, moisture transmitting, water swellable agents are selected from the group consisting of water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch-acrylonitrile graft copolymers, and water insoluble cross-linked dextran, and said flexible backing member is selected from the group consisting of polymeric films, woven and nonwoven fabrics, and polymeric foams.

Claim 4

An adhesive dressing of Claim 2 wherein said pharmaceutically active ingredient is incorpor­ated or deposited at the skin contacting surface by dispersing the active ingredient in a medium which is compatible with the composition of the adhesive layer, casting such dispersion on release paper, and then laminating said coated release paper onto the skin contacting surface of said adhesive layer wherein said dispersing medium is selected from the group consisting of mineral oil and thickened mineral oil.

Claim 5

An adhesive dressing of Claim 3 wherein said pharmaceutically active ingredient is a topically active anti-inflammatory agent.

Claim 6

An adhesive dressing of Claim 4 wherein said anti-inflammatory agent is triamcinolone acetonide and said dispersing medium is thickened mineral oil.

Claim 7

An adhesive dressing of Claim 5 wherein said skin contacting adhesive layer prior to incorporation of the active ingredient comprises: a) about 8% by weight of low molecular weight polyisobutylene, about 6% by weight of a styrene-isoprene-styrene block polymer, about 16.25% by weight of butyl rubber, about 12.75% by weight of tackifier, about 11.5% by weight of mineral oil, about 0.5% by weight of antioxidant, about 15% by weight of sodium carboxymethylcellulose, about 15% by weight of pectin, and about 15% by weight of gelatin; or b) about 9.55% by weight of low molecular weight polyisobutylene, about 20.55% by weight of a styrene-isoprene-styrene block copolymer, about 12.8% tackifier, about 20.45% mineral oil, about 1.55% antioxidant, 25.7% sodium carboxymethyl­cellulose, and about 9.4% water insoluble cross-­linked sodium carboxymethylcellulose; or c) about 9.5% by weight of low molecular weight polyisobutylene, about 9.5% by weight of medium molecular weight polyisobutylene, about 14.4% by weight of mineral oil, about 22.2% by weight of sodium carboxymethylcellulose, about 22.2% by weight of pectin, and about 22.2% by weight of gelatin; or d) about 40% by weight of low molecular weight polyisobutylene, about 20% by weight of pectin, about 20% by weight of gelatin, and about 20% by weight sodium carboxymethylcellulose.

Claim 10

The process of Claim 7 wherein said dispersing medium is selected from the group consisting of mineral oil and thickened mineral oil.

Claim 11

The process of Claim 8 wherein said pharmaceutically active ingredient is a topically active anti-inflammatory agent.

Claim 12

The process of Claim 9 wherein said anti­inflammatory agent is triamcinolone acetonide and said dispersing medium is thickened mineral oil, said skin contacting adhesive layer prior to incorporation of the pharmaceutically active ingredient comprises from about 15% to about 50% by weight of one or more low molecular weight polyisobutylenes or blends of one or more low molecular weight polyiso­butylenes and one or more elastomers, from about 20% to about 70% by weight of one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, up to about 25% by weight of mineral oil, and up to about 20% by weight of tackifiers, said elastomer if present is selected from the group consisting of butyl rubber, medium and high molecular weight polyisobutylenes, and styrene radial or block copolymers, said moisture absorbing, moisture transmitting, water soluble agents are selected from the group consisting of sodium carboxymethylcellulose, calcium carboxy­methylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, xanthan gum, mixed sodium/­calcium salts of alginic acid, and carrageenan said moisture absorbing, moisture transmitting, water swellable agents are selected from the group consisting of a water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch­acrylonitrile graft copolymers, and water insoluble cross-linked dextrab, and said flexible backing member is selected from the group consisting of polymeric films, woven and nonwoven fabrics, and polymeric foams.