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EP0340741A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Polyethylene glycol derivatives, modified peptides and production thereof

Assignee: Sumitomo Pharma Co Ltd
•
Filing: 1989-05-03
•
Granted: —
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Expires: 2009-05-03
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Abstract

Abstract A polyethylene glycol derivative of the formula wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof. The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.

Inventors

  • 👤 Akihiko Sano
  • 👤 Hiroo Maeda
  • 👤 Yoshiyuki Kai
  • 👤 Keiichi Ono

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-30 00:53
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/321; C08G65/323; C07; C07K; C07K1/00; C07K1/06; C07K1/061; C07K1/064; C07K1/107; C07K1/1072; C07K1/1077; C08G65/329; C08G65/334; C08G65/3344; C08G65/3346

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 36 words
(1) A polyethylene glycol derivative of the formula wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000.
Claim 2
Dependent Claim 14 words
(2) A polyethylene glycol derivative as claimed in claim 1 which is 4-monomethoxypolyethylene glycol-phenylglyoxal.
Claim 3
Dependent Claim 21 words
(3) A modified peptide in which the guanidino group is modified by a polyethylene glycol derivative as claimed in claim 1.
Claim 4
Dependent Claim 49 words
(4) A modified peptide as claimed in claim 3 which is selected from among plasminogen activators modified by 4-monomethoxypolyethylene glycol-phenylglyoxal, growth hormone-releasing factors modified by 4-monomethoxypoly­ethylene glycol-phenylglyoxal, granulocyte macrophage colony-stimulating factors modified by 4-monomethoxypoly­ethylene glycol-phenylglyoxal, superoxide dismutases modified by 4-monomethoxypolyethylene glycol-phenylglyoxal and insulin-like growth factors modified by 4-monomethoxy­polyethylene glycol-phenylglyoxal.
Claim 5
Dependent Claim 26 words
(5) A method for producing a modified peptide which comprises reacting a polyethylene glycol derivative as claimed in claim 1 with a peptide having guanidino group.
Claim 6
Dependent Claim 45 words
(6) A method for producing a modified peptide as claimed in claim 3 which comprises protecting the amino group(s) of a peptide, and then reacting the amino-protected peptide with a polyethylene glycol derivative as claimed in claim 1, followed by deprotection of the amino-protective group(s).

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