EP0343696A2
Expired / Lapsed
EP
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Zinc-associated somatotropins
Assignee: Monsanto Co
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Filing: 1985-10-03
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Granted: —
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Expires: 2005-10-03
Abstract
Abstract Metal-associated somatotropins are useful for prolonged parenteral release of such somatotropins, for example release from compositions in which the metal-associated somatotropin is present in a biocompatible oil in an amount of at least 10% by weight of the composition.
Inventors
- 👤 James William Mitchell
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 06:37
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/44; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K47/06; A61K47/08; A61K47/12; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
8 words
A somatotropin chemically associated with non-toxic polyvalent metal.
Claim 2
Dependent Claim
8 words
A somatotropin chemically associated with non-toxic polyvalent metal.
Claim 3
Dependent Claim
28 words
A somatotropin of Claim 1 wherein said metal is not chemically associated in substantial proportion with other anions that form salts having low water solubility with said metal.
Claim 4
Dependent Claim
10 words
A somatotropin of Claim 1, said metal being predominantly zinc.
Claim 5
Dependent Claim
20 words
A somatotropin of Claim 1 chemically associated with from about 0.3% to about 2% zinc by weight of said somatotropin.
Claim 6
Dependent Claim
10 words
A somatotropin of Claim 4 which is a bovine somatotropin.
Claim 7
Dependent Claim
23 words
A process which comprises precipitating a somatotropin from aqueous solution by adding to said solution a water-soluble salt of a non-toxic polyvalent metal.
Claim 8
Dependent Claim
23 words
A process which comprises precipitating a somatotropin from aqueous solution by adding to said solution a water-soluble salt of a non-toxic polyvalent metal.
Claim 9
Dependent Claim
10 words
A process of Claim 6 wherein the metal is zinc.
Claim 10
Dependent Claim
10 words
A process of Claim 7 wherein the somatotropin is bovine.
Claim 11
Dependent Claim
11 words
A process of Claim 8 wherein said salt is zinc chloride.
Claim 12
Dependent Claim
38 words
A somatotropin-containing composition for use in a parenteral release formulation having biological compatibility with an animal, comprising a somatotropin associated with a metal selected from zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium.
Claim 13
Dependent Claim
38 words
A somatotropin-containing composition for use in a parenteral release formulation having biological compatibility with an animal, comprising a somatotropin associated with a metal selected from zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium.
Claim 14
Dependent Claim
11 words
A somatotropin-containing composition of Claim 10 wherein the somatotropin is porcine.
Claim 15
Dependent Claim
11 words
A somatotropin-containing composition of Claim 11 wherein the metal is copper.
Claim 16
Independent Claim
47 words
A method of preparing a somatotropin composition for use in a parenteral release formulation having biological compatibility with an animal, comprising bringing into reactive contact a somatotropin and ions of a metal selected from zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium.
Claim 17
Independent Claim
47 words
A method of preparing a somatotropin composition for use in a parenteral release formulation having biological compatibility with an animal, comprising bringing into reactive contact a somatotropin and ions of a metal selected from zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium.
Claim 18
Dependent Claim
18 words
A method of Claim 12 wherein the ions are provided by a water soluble compound of the metal.
Claim 19
Dependent Claim
10 words
A method of Claim 14 wherein the somatotropin is porcine.
Claim 20
Dependent Claim
10 words
A method of Claim 15 wherein the metal is copper.
References Cited (Backward Citations)
No citation records indexed.
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