Benzimidazole derivatives, their preparation and use

Abstract

Abstract A compound having the formula wherein R 1 is hydrogen, NH 2 or C 1 6 -alkyl which may be branched; X is O, S, NCN; Y is O, S; R 4 , R 5 , R 6 and R 7 independently of each other is hydrogen, halogen, CF 3 , N0 2 , NH 2 , OH, C 1 6 -alkoxy, C(=O)-phenyl or S0 2 NR'R" wherein R' and R" independently are hydrogen or C 1 6 -alkyl; R 11 is hydrogen, halogen, N0 2 or S0 2 NR'R" wherein R' and R" independently are hydrogen or C 1 6 -alkyl; R 13 is hydrogen, halogen, phenyl, CF 3 , N0 2 ; R 12 is hydrogen or together with R 13 forms a C 4 7 - carbocyclic ring which may be aromatic or partial saturated; R14 is hydrogen or together with R 13 forms a C 4 7 - carbocyclic ring which may be aromatic or partial saturated; further a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above.

Inventors

• 👤 Soren-Peter Olesen
• 👤 Frank Wätjen

Bibliographic Details