EP0575712A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Spectrophotometric blood analysis
Assignee: Coretech Medical Technologies Corp
•
Filing: 1993-03-30
•
Granted: —
•
Expires: 2013-03-30
Abstract
Abstract A method and device are described which are particularly useful for continuous on-line monitoring of hematocrit and other blood parameters. The effect of change in blood electrolyte composition, for example, in blood sodium concentration, is taken into consideration. This effect has been found to change light beam geometry, and is taken advantage of to provide for blood sodium concentration measurement. The devices may be applied to extracorporeal circuits or to body parts capable of being transilluminated. The devices may be used to optimize dialysis, and also for monitoring optically detectable, exogenous macromolecules.
Inventors
- 👤 Luis Oppenheimer
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 04:26
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14535; A61B5/1455; A61B5/14551; A61B5/14557; A61M; A61M1/00; A61M1/36; A61M1/3607; A61M1/3609; G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/49; G01N21/53; G01N21/532; G01N15/00; G01N15/04; G01N15/05; G01N2015/055; G01N21/01; G01N21/03; G01N2021/0364; G01N21/25; G01N21/31; G01N21/314; G01N2021/3144
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
87 words
A method for optically determining blood parameters, said method comprising directing a light beam into a patient's blood; detecting the light emerging from the blood, comprising detecting any change in scatter of said light beam, and any change associated with directly emerging light; and separately evaluating any loss in connection with one such change and any gain in connection with the other such change by comparison to a reference, to take into account the effect of change in the light scatter, so as to provide corrected values.
Claim 2
Independent Claim
87 words
A method for optically determining blood parameters, said method comprising directing a light beam into a patient's blood; detecting the light emerging from the blood, comprising detecting any change in scatter of said light beam, and any change associated with directly emerging light; and separately evaluating any loss in connection with one such change and any gain in connection with the other such change by comparison to a reference, to take into account the effect of change in the light scatter, so as to provide corrected values.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein blood concentration of endogenous, optically detectable macromolecules is determined.
Claim 4
Dependent Claim
9 words
The method of claim 1, wherein hematocrit is determined.
Claim 5
Dependent Claim
24 words
The method of claim 1, further comprising directing light of a second wavelength into the blood and detecting emerging light of said second wavelength.
Claim 6
Dependent Claim
17 words
The method of claim 4, wherein said second wavelength is selected to detect exogenous, optically detectable macromolecules.
Claim 7
Dependent Claim
17 words
The method of claim 1, wherein said light beam is directed into a circuit containing flowing blood.
Claim 8
Dependent Claim
20 words
A method of fluid management comprising carrying out the method of claim 1 to monitor changes in the fluid balance.
Claim 9
Dependent Claim
23 words
The method of claim 7, further comprising administering to the patient, a suitable therapeutic agent in an amount sufficient to assist fluid removal.
Claim 10
Dependent Claim
24 words
A method of fluid management comprising carrying out the method of claim 1 and using the information obtained to regulate rate of fluid removal.
Claim 11
Dependent Claim
23 words
The method of claim 9, further comprising administering to the patient, a suitable therapeutic agent in an amount sufficient to assist fluid removal.
Claim 12
Independent Claim
93 words
A device for optically determining blood parameters, said device comprising means for generating a light beam to be directed into a patient's blood; first detecting means and second detecting means each disposed at a suitable location to be sensitive to any change in scatter of said light beam, but differently disposed with respect to said light beam, wherein said location for said first detecting means provides for directly emerging light to be predominantly detected; and signal evaluation means in operative and separate communication with said first detecting means and said second detecting means.
Claim 13
Independent Claim
93 words
A device for optically determining blood parameters, said device comprising means for generating a light beam to be directed into a patient's blood; first detecting means and second detecting means each disposed at a suitable location to be sensitive to any change in scatter of said light beam, but differently disposed with respect to said light beam, wherein said location for said first detecting means provides for directly emerging light to be predominantly detected; and signal evaluation means in operative and separate communication with said first detecting means and said second detecting means.
Claim 14
Dependent Claim
13 words
The device of claim 11, wherein said detecting means are light detecting means.
Claim 15
Dependent Claim
20 words
The device of claim 11, wherein said means for generating a light beam, emits a wavelength in the infrared range.
Claim 16
Independent Claim
119 words
A method for optically determining the blood concentration of macromolecules useful in evaluating exchange properties of blood vessels of a patient, comprising adding to the blood of the patient, a macromolecular mixture comprising a first macromolecular component characterized by a first vascular transport-affecting property and a first optically detectable property, and a second macromolecular component characterized by a second vascular transport-affecting property and a second optically detectable property, wherein said first and second transport-affecting properties differently affect transvascular transport, and wherein said first optically detectable property is optically distinct from said second optically detectable property; and optically detecting change in blood concentration of at least one component of said macromolecular mixture, using a wavelength appropriate for each component determined.
Claim 17
Independent Claim
119 words
A method for optically determining the blood concentration of macromolecules useful in evaluating exchange properties of blood vessels of a patient, comprising adding to the blood of the patient, a macromolecular mixture comprising a first macromolecular component characterized by a first vascular transport-affecting property and a first optically detectable property, and a second macromolecular component characterized by a second vascular transport-affecting property and a second optically detectable property, wherein said first and second transport-affecting properties differently affect transvascular transport, and wherein said first optically detectable property is optically distinct from said second optically detectable property; and optically detecting change in blood concentration of at least one component of said macromolecular mixture, using a wavelength appropriate for each component determined.
Claim 18
Dependent Claim
56 words
The method of claim 14, wherein change in blood concentration of said first macromolecular component and of said second macromolecular component of said macromolecular mixture is optically detected, using a first wavelength appropriate for said first optically detectable property, and a second wavelength distinct from said first wavelength and appropriate for said second optically detectable property.
Claim 19
Dependent Claim
22 words
The method of claim 14, wherein said transvascular transport-affecting properties are selected from the group consisting of molecular weight, charge and rigidity.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.