EP0619116A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Use of synthetic retinoids for osteopathy
Assignee: Shudo Koichi Prof Dr
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Filing: 1994-03-30
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Granted: —
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Expires: 2014-03-30
Abstract
Abstract An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.
Inventors
- 👤 Koichi Shudo
- 👤 Tatsuo Sugioka
- 👤 Mizuho Inazu
- 👤 Hideyuki Tanaka
- 👤 Tsutomu Inoue
- 👤 Kazuyuki Kitamura
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 15:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/655; A61K31/185; A61K31/19; A61K31/192; A61K31/195; A61K31/196; A61K31/33; A61K31/335; A61K31/336; A61K31/35; A61K31/352; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
191 words
An anti-osteopathic composition comprising as an active ingredient a compound of the formula (I): wherein R₁, R₂, R₃, R₄ and R₅ independently represent a hydrogen atom, a lower or middle alkyl group, or a lower or middle alkoxy group, with the proviso that all of R₁, R₂, R₃, R₄ and R₅ do not simultaneously represent hydrogen atoms, any two adjacent groups selected from these groups may combine to form a 5- or 6-membered cycloalkyl ring together with carbon atoms substituted by those groups and the cycloalkyl ring may further be substituted with one or more lower alkyl groups; R₆ represents a hydroxyl group, a lower alkoxy group, or -NR₇R₈ group in which R₇ and R₈ independently represent a hydrogen atom or a lower alkyl group; X represents a radical selected from the group consisting of the radicals represented by the following formulas: and wherein R₉ and R₁₀ independently represents a hydrogen atom or a lower alkyl group and; Y represents a radical selected from the group consisting of the radicals represented by the following formulas: wherein W represents a hydrogen atom or a hydroxy group, or a salt of said compound.
Claim 2
Dependent Claim
120 words
The anti-osteopathic composition according to claim 1, wherein the active ingredient is a compound or a salt of the compound selected from the group consisting of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carboxamide]benzoic acid (hereinafter referred to as "Am580"), 4-[(3,4-diisopropylphenyl)carboxamide]benzoic acid, 5-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamide]pyridine-2-carboxylic acid, 6-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamide]pyridine-3-carboxylic acid, 3-hydroxy-4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamide]benzoic acid (hereinafter referred to as "Am589"), 4-[(3-isopropyl-4-isopropoxyphenyl)carboxamide]benzoic acid (hereinafter referred to as "Am685"), 3-hydroxy-4-[(3-isopropyl-4-isopropoxyphenyl)carboxamide]-benzoic acid (hereinafter referred to as "Am689"), 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid (hereinafter referred to as "Am80"), 4-[(3,4-diisopropylphenyl)carbamoyl]benzoic acid, 5-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]pyridine-2-carboxylic acid, (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid (hereinafter referred to as "Ch55"), (E)-4-[3-(3,5-diisopropylphenyl)-3-oxo-1-propenyl]benzoic acid, 6-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]pyridine-3-carboxylic acid (hereinafter referred to as "R300"), 4-[3-methyl-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)oxylanyl]benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)azoxy]benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)azo]benzoic acid, 4-[(3,5-di-tert-butylphenyl)carboxamide]benzoic acid, 4-[(3,5-di-tert-butylphenyl)carbamoyl]benzoic acid, 5-[(3,4-diisopropylphenyl)carboxamide]pyridine-2-carboxylic acid, 6-[(3,4-diisopropylphenyl)carboxamide]pyridine-3-carboxylic acid, 5-[(3,4-diisopropylphenyl)carbamoyl]pyridine-2-carboxylic acid, 6-[(3,4-diisopropylphenyl)carbamoyl]pyridine-3-carboxylic acid, 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-oxyranyl]benzoic acid (hereinafter referred to as "Ep80"), 4-[(3,4-diisopropylphenyl)azo]benzoic acid (hereinafter referred to as "Az68").
Claim 3
Dependent Claim
17 words
The anti-osteopathic composition according to claim 1 or 2, wherein the active ingredient is 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamide]benzoic acid (Am580).
Claim 4
Dependent Claim
97 words
An anti-osteopathic composition comprising as an active ingredient a compound of formula (II) or (III) wherein R₁₁ and R₁₂ independently represent a hydrogen atom or a lower or middle alkyl group or R₁₁ and R₁₂ may combine to form a 6-membered cycloalkyl ring together with carbon atoms substituted by these groups and said cycloalkyl ring may contain an oxygen atom and may be substituted by one or more lower alkyl groups; R₁₃ represents a hydrogen atom or a lower alkyl group; and W represents a hydrogen atom or a hydroxy group, or a salt of said compound.
Claim 5
Dependent Claim
46 words
The anti-osteopathic composition as claimed in claim 4, wherein the active ingredient is a compound or a salt thereof selected from the group consisting of 4-(6,7,8,9-tetrahydro-3-hydroxy-6,6,9,9-tetramethyl-4H-4-oxonaphtho[2.3-b]pyran-2-yl)benzoic acid (hereinafter referred to as "Fv180"), 4-(6,7,8,9-tetrahydro-6,6,9,9-tetramethyl-4H-4-oxonaphtho[2.3-b]pyran-2-yl)-benzoic acid (hereinafter referred to as "Fv80"), 4-[1-hydroxy-3-oxo-3-(5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid (hereinafter referred to as "Re80").
Claim 6
Dependent Claim
15 words
The anti-osteopathic composition according to claims 1 - 5 useful for therapeutic treatment of osteopathia.
Claim 7
Dependent Claim
16 words
The anti-osteopathic composition according to claim 6 wherein the osteopathia is osteoporosis or a bone fracture.
Claim 8
Dependent Claim
15 words
The anti-osteopathic composition according to claims 1 - 5 useful for prophylactic treatment of osteopathia.
Claim 9
Dependent Claim
12 words
The anti-osteopathic composition according to claim 8 wherein the osteopathia is osteoporosis.
Claim 10
Dependent Claim
23 words
A compound selected from the group consisting of 4-[(3-isopropyl-4-isopropoxyphenyl)carboxamide]benzoic acid (hereinafter referred to as "Am685") and 3-hydroxy-4-[(3-isopropyl-4-isopropoxyphenyl)carboxamide]-benzoic acid (hereinafter referred to as "Am689").
References Cited (Backward Citations)
EP0170105A2
Cited
EP0232199A2
Cited
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