EP0780680A2
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EP
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Analyzer for analyzing urine material components
Assignee: Sysmex Corp
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Filing: 1996-12-18
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Granted: —
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Expires: 2016-12-18
Abstract
Abstract An analyzer for analyzing urine material components includes: a sheath flow cell for forming a sample stream containing the urine material components ; a light source for illuminating the sample stream; a section for detecting optical information from the illuminated material component particles; and an analyzing section for analyzing the material components; the analyzing section including section for extracting parameters from the detected optical information, a section for generating first and second distribution diagrams on the basis of the extracted parameters, an inputting section for inputting a domain in the first distribution diagrams, a domain determining section for clustering the material component particles according to the kind of material component to define a domain for each of the material components in at least one of the first and second distribution diagrams, and a section for computing the number of data points of material component particles simultaneously belonging to a domain in the first distribution diagram inputted from the inputting section and a domain in the second distribution diagram defined by the domain determining section.
Inventors
- 👤 Masayuki Katayama
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 00:31
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/493; G01N15/00; G01N15/10; G01N15/14; G01N15/1456
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
215 words
An analyzer for analyzing urine material components which comprises: a sheath flow cell for forming a sample stream by surrounding a sample liquid containing preliminarily stained particles of the urine material components with a sheath fluid; a light source for illuminating the sample stream; a photodetecter section for detecting optical information from the illuminated material component particles; and an analyzing section for analyzing the material components on the basis of the detected optical information; wherein the analyzing section includes: a parameter extracting section for extracting a plurality of parameters from the detected optical information; a distribution diagram generating section for generating first and second distribution diagrams on the basis of the extracted parameters; an inputting section for inputting a domain in at least one of the first and second distribution diagrams; a domain determining section for clustering the material component particles according to the kind of material component to define a domain for each of the material components in at least one of the first and second distribution diagrams; and a computing section for computing the number of data points of material component particles simultaneously belonging to a first domain in the first distribution diagram inputted from the inputting section and a second domain in the second distribution diagram defined by the domain determining section.
Claim 2
Dependent Claim
34 words
An analyzer as set forth in claim 1, wherein the plurality of parameters to be extracted include a fluorescent light intensity Fl, a scatter light intensity Fsc and a scatter light emission duration Fscw.
Claim 3
Dependent Claim
57 words
An analyzer as set froth in claim 2, wherein the first distribution diagram is a scattergram generated on the basis of the fluorescent light intensity Fl and the scatter light intensity Fsc, and the second distribution diagram is a scattergram generated on the basis of the scatter light emission duration Fscw and the fluorescent light intensity Fl.
Claim 4
Dependent Claim
47 words
An analyzer as set forth in claim 3, wherein the first domain is an area where data points of material component particles except streptobacillus are located, and the second domain is an area where data points of hemolytic-state erythrocytes and data points of the streptobacillus are located.
Claim 5
Dependent Claim
35 words
An analyzer as set forth in claim 4, wherein the number of the data points simultaneously belonging to the first and second domains is computed for determination of the number rl of the hemolytic-state erythrocytes.
Claim 6
Dependent Claim
83 words
An analyzer as set forth in claim 5, wherein the domain determining section defines a third domain and a fourth domain in the first distribution diagram and, when the number of data points attributed to one material component in the third domain is smaller than a predetermined number, the computing section judges that no data point attributed to the one material component is present in the fourth domain and computes the number of data points of material component particles in the fourth domain.
Claim 7
Dependent Claim
50 words
An analyzer as set forth in claim 6, wherein the third domain is an area where data points of the streptobacillus are located, and the number of the data points of the material component particles in the fourth domain is computed for determination of the number r2 of hemolytic-state erythrocytes.
Claim 8
Dependent Claim
42 words
An analyzer as set froth in claim 7, wherein the computing section further has a function for computing the number of data points of material component particles in a fifth domain in the first distribution diagram defined by the domain determining section.
Claim 9
Dependent Claim
35 words
An analyzer as set forth in claim 8, wherein the number of the data points of the material component particles in the fifth domain is computed for determination of the number R of nonhemolytic-state erythrocytes.
Claim 10
Dependent Claim
25 words
An analyzer as set forth in claim 9, wherein the computing section further has a function for computing the total number of erythrocytes from r1+r2+R.
Claim 11
Dependent Claim
27 words
An analyzer as set forth in claim 10, wherein the computing section further has a function for computing the ratio h of the hemolytic-state erythrocytes from h=(r1+r2)/(R+r1+r2).
Claim 12
Dependent Claim
31 words
An analyzer as set froth in claim 11, wherein the analyzing section further includes a warning section for giving a warning when the ratio h is greater than a predetermined value.
Claim 13
Dependent Claim
128 words
A process for analyzing urine material components, comprising the steps of: forming a sample stream by surrounding a sample liquid containing preliminarily stained particles of the urine material components with a sheath fluid; illuminating the sample stream; detecting optical information from the illuminated material component particles; extracting a plurality of parameters from the detected optical information; generating first and second distribution diagrams on the basis of the extracted parameters; inputting a first domain where data points of material component particles except streptobacillus are located in the first distribution diagram; defining a second domain where data points of erythrocytes and streptobacillus are located in the second distribution diagram; and computing the number of data points of material component particles simultaneously belonging to the first domain and the second domain.
Claim 14
Independent Claim
17 words
A method of analyzing erythrocytes using the analyzer defined in any one of claims 1 through 12.
References Cited (Backward Citations)
EP0242971A2
Cited
JPH04337459A
Cited
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