EP0781566A2
Expired / Lapsed
EP
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Organic solvent-soluble mucopolysaccharide, antibacterial antithrombogenic composition and medical material
Assignee: Toyobo Co Ltd
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Filing: 1996-12-20
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Granted: —
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Expires: 2016-12-20
Abstract
Abstract The present invention relates to an organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide (preferably heparin or heparin derivative) and a quaternary phosphonium, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an organic polymer material, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an antibacterial agent (preferably inorganic antibacterial agent such as silver zeolite), and to a medical material comprising said organic solvent-soluble mucopolysaccharide. The organic solvent-soluble mucopolysaccharide, and the antibacterial antithrombogenic composition and medical material containing the same, of the present invention, can easily impart antithrombogenicity and antibacterial property to a polymer to be a base material, which properties being maintained not only immediately after preparation of the material but also after long-term elution. Thus, the organic solvent-soluble mucopolysaccharide and antibacterial antithrombogenic material of the present invention show superior applicability as a material to impart antithrombogenicity and antibacterial ability to medical materials.
Inventors
- 👤 Hideyuki c/o Toyo Boseki K.K. Yokota
- 👤 Masakazu c/o Toyo Boseki K.K. Tanaka
- 👤 Masahiro c/o Toyo Boseki K.K. Seko
- 👤 Noriko c/o Toyo Boseki K.K. Monden
- 👤 Susumu c/o Toyo Boseki K.K. Arimori
- 👤 Shigeji c/o Toyo Boseki K.K. Konagaya
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 07:31
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L33/00; A61L33/0005; A61L33/0011; A61L33/06; A61L33/08; C08L; C08L101/00; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/404; A61L2300/42; A61L2300/45; C08L2203/00; C08L2203/02
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
18 words
An organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide and a quaternary phosphonium.
Claim 2
Dependent Claim
21 words
The organic solvent-soluble mucopolysaccharide of claim 1, comprising at least one member selected from heparin and heparin derivatives as the mucopolysaccharide.
Claim 3
Dependent Claim
67 words
The organic solvent-soluble mucopolysaccharide of claim 1 or 2, wherein the quaternary phosphonium has the formula (I) wherein R 1 , R 2 and R 3 are the same or different and each is alkyl having 1 to 12 carbon atoms, aryl having 6 to 12 carbon atoms or aralkyl having 7 to 20 carbon atoms, and R 4 is alkyl having 1 to 25 carbon atoms.
Claim 4
Dependent Claim
22 words
An antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 and an organic polymer material.
Claim 5
Dependent Claim
26 words
The composition of claim 4, wherein the organic polymer material is selected from the group consisting of poly(vinyl halide), poly(vinylidene halide), polyurethane, polyurethaneurea, polyester and polyamide.
Claim 6
Dependent Claim
25 words
An antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3, an organic polymer material and an antibacterial agent.
Claim 7
Dependent Claim
26 words
The composition of claim 6 wherein the organic polymer material is selected from the group consisting of poly(vinyl halide), poly(vinylidene halide), polyurethane, polyurethaneurea, polyester and polyamide.
Claim 8
Dependent Claim
14 words
The composition of claim 6 wherein the antibacterial agent is an inorganic antibacterial agent.
Claim 9
Dependent Claim
34 words
The composition of claim 8 wherein the inorganic antibacterial agent is at least one member selected from the group consisting of silver zeolite, silver zirconium phosphate complex, silver ceramics, silver silica and antibacterial glass.
Claim 10
Dependent Claim
42 words
The composition of claim 8 which comprises 0.1 - 50 parts by weight of the organic solvent-soluble mucopolysaccharide and 0.1 - 50 parts by weight of the inorganic antibacterial agent, both relative to 100 parts by weight of the organic polymer material.
Claim 11
Dependent Claim
21 words
An antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 and an antibacterial agent.
Claim 12
Dependent Claim
14 words
The composition of claim 11 wherein the antibacterial agent is an inorganic antibacterial agent.
Claim 13
Dependent Claim
34 words
The composition of claim 12 wherein the inorganic antibacterial agent is at least one member selected from the group consisting of silver zeolite, silver zirconium phosphate complex, silver ceramics, silver silica and antibacterial glass.
Claim 14
Dependent Claim
16 words
A medical material comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3.
Claim 15
Dependent Claim
21 words
A medical material comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 and an organic polymer material.
Claim 16
Dependent Claim
24 words
A medical material comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3, an organic polymer material and an antibacterial agent.
Claim 17
Independent Claim
31 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises admixing the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 with the medical material.
Claim 18
Independent Claim
31 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises coating the medical material with the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3.
Claim 19
Independent Claim
41 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises admixing an antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 and an organic polymer material with the medical material.
Claim 20
Independent Claim
41 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises coating the medical material with an antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3 and an organic polymer material.
Claim 21
Independent Claim
44 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises admixing an antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of any one of claims 1 to 3, an organic polymer material and an antibacterial agent with the medical material.
Claim 22
Independent Claim
41 words
A method for imparting antibacterial property and antithrombogenicity to a medical material, which comprises coating the medical material with an antibacterial antithrombogenic composition comprising the organic solvent-soluble mucopolysaccharide of claims 1 to 3, an organic polymer material and an antibacterial agent.
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