Preparation of n-methyl-benzthiazolone derivative

Abstract

Abstract PURPOSE: To obtain an N-methylbenzthiazolone derivative useful as pesticides and medicines, readily almost quantitatively under very mild conditions, by rearranging a 2-methoxybenzthiazole derivative in the presence of a dialkyl sulfate under heating. CONSTITUTION: A 2-methoxybenzthiazole derivative of formula I: (R is H, halogen, or lower alkyl group) is rearranged in the presence of a dialkyl sulfate, preferably dimethyl or diethyl sulfate, more preferably dimethyl sulfate, with or without an organic solvent, to give an N-methylbenzthiazolone derivative of formula II. A large amount of the dialkyl sulfate is advantageous to the rate of reaction, however, 1/100W1/10 mole per mole of the campound of formula I is preferred. The reaction temperature is above the melting point of the compound of formula II, usually 10W20°C higher than the point in the absence of the solvent, and near the reflux temperature of the solvent in the presence of it. COPYRIGHT: (C)1980,JPO&Japio

Inventors

• 👤 Haruki Morino
• 👤 Takeaki Umemura
• 👤 Tetsuhiko Watanabe
• 👤 Tamon Uematsu

Bibliographic Details