11-deoxoglycyrrhetinic hydrogenmaleate and medicine containing the same as active constituent

Abstract

Abstract NEW MATERIAL:11-Deoxoglycyrrhetinic hydrogenmaleate of the formula or a salt thereof. USE:A remedy for ulcer, immunological activating agent for delayed cells and anti-inflammatory agent, characterized by no side effects, and used in a daily does of 1.0-20mg for an injection and 50-500mg for an oral agent in an adult. PROCESS:Glycyrrhetinic acid is catalytically reduced in a solvent in the presence of a catalyst,e.g. platinum, to give 11-deoxoglycyrrhetinic acid, which is then reacted with maleic anhydride to afford the compound of the formula. The latter reaction is preferably carried out in a solvent, e.g. dioxide, at the boiling temperature of the reaction mixture.

Inventors

• 👤 Shigeru Toyoshima
• 👤 豊島　滋
• 👤 Hajime Fujimura
• 👤 一 藤村
• 👤 Shunsuke Ito
• 👤 俊介 伊藤
• 👤 Yasuharu Kondo
• 👤 近藤　安治

Bibliographic Details