Preparation of liposome

Abstract

Abstract PURPOSE:To prepare uniform liposome with good reproducibility by mixing a substance constituting liposome membrane with water-soluble nonvolatile org. solvent, then dispersing the mixture in aq. soln. CONSTITUTION:A component substance of liposome membrane (e.g. phosphatidyl choline) is mixed with ca.1-100 times weight of water-soluble nonvolatile solvent (e.g. glycerine), then, the mixture is dispersed in aq. soln. (e.g. water). By this method, uniform liposome is prepd. with good reproducibility. It is characterised that water-soluble organic solvent which is harmless to living body and can be administered even if it remains as it is in the final product is used for the dissolving agent for the substance composing the membrane. Incorporation of a medical substance into liposome obtd. by this method is realized by mixing and stirring a mixture contg. the membrane composing substance in an org. solvent with an aq. soln. contg. the medicine.

Inventors

• 👤 Hiroshi Kikuchi
• 👤 寛 菊池
• 👤 Hitoshi Yamauchi
• 👤 仁史 山内

Bibliographic Details