Carcinostatic magnetic vesicular material composition

Abstract

Abstract PURPOSE:The titled composition effective for hyperthermia, attacking effectively cancerous cells or being attached to them, comprising magnetic vesicular material, obtained by forming a lipid molecular layer or a lipid molecular layer including a functional molecule on the outer peripheries of magnetic particles having specific particle diameters, as a main component. CONSTITUTION:A composition comprising a magnetic vesicular material, obtained by forming a lipid molecular layer or a lipid molecular layer including a functional molecule (e.g., stearylamine of long-chain amine) to charge the vesicular material positively on the whole on the outer peripheries of magnetic material (e.g., tri-iron tetroxide) having 60Angstrom -1mum particle diameter, as a main component. A phosphatidylcholine shown by the formula (n is 10-21) is preferably used as the lipid molecule. The vesicular material is easily approaches cancerous cells, attacks them effectively or being attached to them, and, when AC magnetic field of electromagnetic wave is applied to them from the outside, heat is generated in them by magnetic hysteresis loss effect, so that only cancerous cells are effectively destroyed.

Inventors

• 👤 Satoru Yamaguchi
• 👤 哲 山口
• 👤 Nobuo Mochida
• 👤 持田　信夫

Bibliographic Details