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NZ200475A
Expired / Lapsed
NZ
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Topical anti-inflammatory compositions containing d-honosteroids
Assignee: Hoffmann La Roche
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Filing: 1982-04-30
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Granted: —
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Expires: 2002-04-30
Abstract
No abstract record available.
Inventors
- 👤 G Klecak
- 👤 M Mueller
Bibliographic Details
Application Number
—
Jurisdiction
NZ
Data Source
google_patents
Last Synchronized
2026-11-02 02:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
138 words
Topically applicable pharmaceutical preparation, containing a D-homosteroid of the formula COR 20 - - R 17a 10 15 in which R signifies hydrogen, methyl, g chlorine or fluorine, R signifies hydrogen, fluorine or chlorine, R"^ signifies oxo or (a-H,/3-0H) , R^a sig- 20 nifies hydroxy or acyloxy, R sig- 201 21 nifies a group -0-R or -CI^-R , R 201 signifies lower-alkyl, chloro- 21 -lower-alkyl or fluoro-lower-alkyl, R signifies hydrogen, chlorine, fluorine, hydroxy or acyloxy and the dotted 1,2--bond signifies an optional C-C bond, and, where R20 is a group -0-R20"*", a double bond can be present in the 16,17--position, - 12 - 200475 and a compound of the formula in which signifies hydrogen, halogen, 2 3 lower-alkyl or lower-alkoxy and R , R and 4 5 R signify hydrogen, lower-alkoxy, hydroxy- -lower-alkoxy or two adjacent symbols R^",
Claim 2
Dependent Claim
138 words
Topically applicable pharmaceutical preparation, containing a D-homosteroid of the formula COR 20 - - R 17a 10 15 in which R signifies hydrogen, methyl, g chlorine or fluorine, R signifies hydrogen, fluorine or chlorine, R"^ signifies oxo or (a-H,/3-0H) , R^a sig- 20 nifies hydroxy or acyloxy, R sig- 201 21 nifies a group -0-R or -CI^-R , R 201 signifies lower-alkyl, chloro- 21 -lower-alkyl or fluoro-lower-alkyl, R signifies hydrogen, chlorine, fluorine, hydroxy or acyloxy and the dotted 1,2--bond signifies an optional C-C bond, and, where R20 is a group -0-R20"*", a double bond can be present in the 16,17--position, - 12 - 200475 and a compound of the formula in which signifies hydrogen, halogen, 2 3 lower-alkyl or lower-alkoxy and R , R and 4 5 R signify hydrogen, lower-alkoxy, hydroxy- -lower-alkoxy or two adjacent symbols R^",
Claim 3
Dependent Claim
86 words
2 3 4 R , R and R together signify methylene- 12 3 dioxy, and at least one symbol R , R , R 4 or R contains oxygen. 10 2. A preparation according to claim 1, wherein the D- -homosteroid of formula I is unsaturated in the 1,2- -position and R® is hydrogen, R^ is hydrogen or fluorine, R^ is (a-H, B-OH) , R^ a is C^_^-alkanoyloxy, is a 21 21 group -CI^-R and R is C^_^-alkanoyloxy, or hydrogen or hydroxy. 20047 - 13 -
Claim 4
Dependent Claim
56 words
A preparation according to claim 1 or 2, wherein in the D-homosteroid of formula I a double bond is present 6 9 11 in the 1,2-position and R and R are hydrogen, R is (a-H, g-OH) , R"^a is propionyloxy or butyryloxy, R^ is 21 21 a group -CH^R and R is acetoxy, hydroxy or hydrogen.
Claim 5
Dependent Claim
18 words
A preparation according to any one of claims 1-3, wherein the D-homosteroid is 17a-butyryloxy-ll0-hydroxy- - D-homopregna-1, 4-diene-3, 20-dione.
Claim 6
Dependent Claim
35 words
A preparation according to any one of claims 1-4, 1 4 wherein in the compound of formula II R and R are 2 3 hydrogen, R is ethoxy, isopropoxy or butoxy and R is methoxy.
Claim 7
Dependent Claim
20 words
6 . A preparation according to any one of claims 1-5 , wherein the compound of formula II is D,L-4-(3-butoxy-4--methoxybenzyl)-2-imidazolidinone.
Claim 8
Dependent Claim
54 words
A preparation according to any one of claims 1-6, wherein the D-homosteroid is 17a-butyryloxy-11(3-hydroxy-D--homopregna-1, 4-diene-3 , 20-dione, 17a-butyryloxy-9-fluoro--110-hydroxy-D-homopregna-l, 4-diene-3, 20-dione , 21-acetoxy- - 9- f luoro-110-hy droxy-17a-propiony loxy-D-homopregna-1,4- A -diene-3,20-dione, 17a-butyryloxy-ll0, 21-dihydro-D-homo-<vpregna-l, 4-aiene-3 , 20-dione or 17a-butyryloxv-21-chloro-9- 2 0 14 RS 4 051/9 -fluoro-110-hydroxy-D-homopregna-l,4-diene-3,20-dione and the compound of formula II is D,L-4-(3-butoxy-4--methoxybenzyl)-2-imidazolidinone or D,L-4-(3-isopropoxy--4-methoxybenzyl)-2-imidazolidinone.
Claim 9
Dependent Claim
44 words
A preparation in accordance with any one of claims 1--7, wherein the D-homosteroid is 17a-butyryloxy-ll3-hydroxy--D-homopregna-1,4-diene-3,20-dione and the compound of formula II is D,L-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone . -..cD THiS SOt-L day OF A. J £ SON Pbl. i // • £ rfe. AGHNT^S F OF'l THE APPLICANTS
References Cited (Backward Citations)
No citation records indexed.
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