US2518978A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hog cholera vaccine
Assignee: Wyeth Holdings LLC
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Filing: 1946-09-12
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Granted: 1950-08-15
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Expires: 1966-09-12
Abstract
No abstract record available.
Inventors
- 👤 Herald R Cox
- 👤 Koprowski Hilary
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:11
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/187; A61K2039/51; A61K2039/525; A61K2039/5254; A61K2039/55; A61K2039/552; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24311; C12N2770/24334
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
186 words
A METHOD OF ESTABLISHING GROWTH OF HOG CHOLERA VIRUS IN RABBITS WHICH COMPRISES THE STEP OF INOCULATING A RABBIT WITH VIRULENT HOG CHOLERA VIRUS AND AFTER A PERIOD OF FROM ABOUT ONE TO SIX DAYS WITHDRAWING VIRUS FROM THE SAID RABBIT AND INOCULATING NON-IMMUNE HOG WITH A SUFFICIENT AMOUNT OF THE VIRUS TO INFECT SAID HOG, ALLOWING THE VIRUS THUS TRANSFERRED TO THE HOG TO PROPAGATE IN SAID HOG, WITHDRAWING A QUANTITY OF THE VIRUS FROM SAID HOG, AND INTRODUCING IT INTO A SECOND RABBIT AND, AFTER A PERIOD OF FROM ABOUT ONE TO SIX DAYS, WITHDRAWING THE VIRUS FROM SAID SECOND RABBIT AND INJECTING IT INTO A SEOND NON-IMMUNE HOG AND REPEATING SAID PROCESS OF ALTERNATING THE VIRUS FROM RABBIT TO HOG UNTIL THE VIRUS IS SO MODIFIED THAT IT WILL PROPAGATE IN THE RABBIT WITHOUT RETURN TO A HOG AND CONTINUING THE PASSAGE OF VIRUS FROM RABBIT TO RABBIT FOR AT LEAST TWENTY PASSAGES WHEREBY THE VIRUS IS SO MODIFIED THAT IT WILL NO LONGER DEVELOP PATHOLOGICAL SYMPTOMS WHEN INJECTED INTO A NORMAL HOG BUT WILL GIVE RISE TO THE PRODUCTION OF PROTECTIVE ANTIBODIES.
Claim 2
Independent Claim
186 words
A METHOD OF ESTABLISHING GROWTH OF HOG CHOLERA VIRUS IN RABBITS WHICH COMPRISES THE STEP OF INOCULATING A RABBIT WITH VIRULENT HOG CHOLERA VIRUS AND AFTER A PERIOD OF FROM ABOUT ONE TO SIX DAYS WITHDRAWING VIRUS FROM THE SAID RABBIT AND INOCULATING NON-IMMUNE HOG WITH A SUFFICIENT AMOUNT OF THE VIRUS TO INFECT SAID HOG, ALLOWING THE VIRUS THUS TRANSFERRED TO THE HOG TO PROPAGATE IN SAID HOG, WITHDRAWING A QUANTITY OF THE VIRUS FROM SAID HOG, AND INTRODUCING IT INTO A SECOND RABBIT AND, AFTER A PERIOD OF FROM ABOUT ONE TO SIX DAYS, WITHDRAWING THE VIRUS FROM SAID SECOND RABBIT AND INJECTING IT INTO A SEOND NON-IMMUNE HOG AND REPEATING SAID PROCESS OF ALTERNATING THE VIRUS FROM RABBIT TO HOG UNTIL THE VIRUS IS SO MODIFIED THAT IT WILL PROPAGATE IN THE RABBIT WITHOUT RETURN TO A HOG AND CONTINUING THE PASSAGE OF VIRUS FROM RABBIT TO RABBIT FOR AT LEAST TWENTY PASSAGES WHEREBY THE VIRUS IS SO MODIFIED THAT IT WILL NO LONGER DEVELOP PATHOLOGICAL SYMPTOMS WHEN INJECTED INTO A NORMAL HOG BUT WILL GIVE RISE TO THE PRODUCTION OF PROTECTIVE ANTIBODIES.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1953-08-14 | 1954-02-13 | 1954-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1957-08-14 | 1958-02-13 | 1958-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1961-08-14 | 1962-02-13 | 1962-08-15 | $7700.00 | Window Closed / Lapsed |