US3626056A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral antibiotic product
Assignee: Bristol Myers Co
•
Filing: 1967-11-02
•
Granted: 1971-12-07
•
Expires: 1987-11-02
Abstract
Abstract An aqueous penicillin suspension comprising coated particles of certain penicillins such as dicloxacillin, the coating comprising ethylcellulose and a pharmaceutically acceptable wax, an aqueous pharmaceutical vehicle and kaolin or colloidal magnesium aluminum silicate when administered orally to animals including man is useful in the treatment of bacterial infections.
Inventors
- 👤 Alphonse Peter Granatek
- 👤 Bernard Charles Nunning
- 👤 Nicholas George Athanas
- 👤 Robert Lewis Dana
- 👤 Edmund Stanley Granatek
- 👤 Raymond George Daoust
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1629; A61K9/1652
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
23 words
The aqueous penicillin suspension of claim 1 having from about 50 to about 125 mg. of penicillin activity per 5 ml. of suspension.
Claim 2
Dependent Claim
23 words
The aqueous penicillin suspension of claim 1 having from about 60 to about 70 mg. of penicillin activity per 5 ml. of suspension.
Claim 3
Dependent Claim
34 words
The aqueous penicillin suspension of claim 1 wherein said coating comprises about 1.7 parts by weight of spermaceti wax and 0.3 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose.
Claim 4
Dependent Claim
54 words
The aqueous penicillin suspension of claim 1 where the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to 33 g. of sucrose, and sufficient water to fill.
Claim 5
Dependent Claim
41 words
The aqueous penicillin suspension of claim 1 containing from about 1 to about 3 parts by weight of kaolin or from about 2 to 5 parts by weight of colloidal magnesium aluminum silicate per part by weight of coated penicillin particles.
Claim 6
Dependent Claim
57 words
The aqueous penicillin suspension of claim 1 hAving from about 50 to about 125 mg. of penicillin activity per 5 ml. of suspension and containing from about 1 to about 3 parts by weight of kaolin or from about 2 to 5 parts by weight of colloidal magnesium aluminum silicate per part by weight of coated penicillin.
Claim 7
Dependent Claim
52 words
The aqueous penicillin suspension of claim 5 having from about 50 to about 125 mg. of penicillin activity per 5 ml. of suspension and containing from about 3 to about 7 grams of kaolin or from about 6 to about 8 grams of colloidal magnesium aluminum silicate per 60 ml. of suspension.
Claim 8
Dependent Claim
52 words
The aqueous penicillin suspension of claim 1 having from about 50 to about 125 mg. of penicillin activity per 5 ml. of suspension and containing from about 3 to about 7 grams of kaolin or from about 6 to about 8 grams of colloidal magnesium aluminum silicate per 60 ml. of suspension.
Claim 9
Dependent Claim
34 words
The aqueous penicillin suspension of claim 9 wherein said coating comprises about 1.7 parts by weight of spermaceti wax and 0.3 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose.
Claim 10
Dependent Claim
12 words
The aqueous penicillin suspension of claim 8 wherein said penicillin is dicloxacillin.
Claim 11
Dependent Claim
12 words
The aqueous penicillin suspension of claim 9 wherein said penicillin is dicloxacillin.
Claim 12
Dependent Claim
12 words
The aqueous penicillin suspension of claim 10 wherein said penicillin is dicloxacillin.
Claim 13
Dependent Claim
55 words
The aqueous penicillin suspension of claim 9 wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill.
Claim 14
Dependent Claim
34 words
The aqueous penicillin suspension of claim 14 wherein said coating comprises about 1.7 parts by weight of spermaceti wax and 0.3 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose.
Claim 15
Dependent Claim
12 words
The aqueous penicillin suspension of claim 14 wherein said penicillin is dicloxacillin.
Claim 16
Dependent Claim
12 words
The aqueous penicillin suspension of claim 15 wherein said penicillin is dicloxacillin.
Claim 17
Dependent Claim
130 words
The aqueous suspension of claim 1 having from about 60 to about 70 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is dicloxacillin and said coated particles comprise about 3 parts by weight of coating per part by weight of dicloxacillin and said coating comprises about 2 parts by weight of spermaceti wax per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 3 to about 7 g. of kaolin.
Claim 18
Dependent Claim
139 words
The aqueous suspension of claim 1 having from about 60 to about 70 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is dicloxacillin and said coated particles comprise about 3 parts by weight of coating per part by weight of dicloxacillin and said coating comprises about 1.7 parts by weight of spermaceti wax and 0.3 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 3 to about 7 g. of kaolin.
Claim 19
Dependent Claim
133 words
The aqueous suspension of claim 1 having from about 60 to about 70 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is dicloxacillin and said coated particles comprise about 3 parts by weight of coating per part by weight of dicloxacillin and said coating comprises about 2 parts by weight of spermaceti wax per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 6 to about 8 g. of colloidal magnesium aluminum silicate.
Claim 20
Dependent Claim
142 words
The aqueous suspension of claim 1 having from about 60 to about 70 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is dicloxacillin and said coated particles comprise about 3 parts by weight of coating per part by weight of dicloxacillin and said coating comprises about 1.7 parts by weight of spermaceti wax and 0.3 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 gm. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 6 to about 8 g. of colloidal magnesium aluminum silicate.
Claim 21
Dependent Claim
126 words
The aqueous suspension of claim 1 having about 125 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is ampicillin and said coated particles comprise about 9 parts by weight of ampicillin per part by weight of coating and said coating comprises about 2 parts by weight of spermaceti wax per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 3 to about 7 g. of kaolin.
Claim 22
Dependent Claim
129 words
The aqueous suspension of claim 1 having about 125 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is ampicillin and said coated particles comprise about 9 parts by weight of ampicillin per part by weight of coating and said coating comprises about 2 parts by weight of spermaceti wax per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 6 to about 8 g. of colloidal magnesium aluminum silicate.
Claim 23
Dependent Claim
135 words
The aqueous suspension of claim 1 having about 125 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is ampicillin and said coated particles comprise about 9 parts by weight of ampicillin per part by weight of coating and said coating comprises about 1.3 parts by weight of spermaceti wax and 0.7 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 G. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 3 to about 7 g. of kaolin.
Claim 24
Dependent Claim
138 words
The aqueous suspension of claim 1 having about 125 mg. of penicillin activity per 5 ml. of suspension, wherein said penicillin is ampicillin and said coated particles comprise about 9 parts by weight of ampicillin per part by weight of coating and said coating comprises about 1.3. parts by weight of spermaceti wax and 0.7 parts by weight of hydrogenated castor oil per part by weight of ethylcellulose; wherein the aqueous pharmaceutical vehicle comprises on the basis of 60 ml. of suspension from about 0.25 to about 0.75 g. of gum tragacanth, from about 0.5 to about 2.4 g. of sodium chloride, from about 5 to about 33 g. of sucrose, and sufficient water to fill; and contains on the basis of 60 ml. of suspension from about 6 to about 8 g. of colloidal magnesium aluminum silicate.
References Cited (Backward Citations)
US2487336A
Cited
US2805977A
Cited
US2902407A
Cited
US2921883A
Cited
US2980589A
Cited
US3214337A
Cited
US3337402A
Cited
US3247065A
Cited
US3317389A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-12-06 | 1975-06-07 | 1975-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-12-06 | 1979-06-07 | 1979-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-12-06 | 1983-06-07 | 1983-12-07 | $7700.00 | Window Closed / Lapsed |