US3645847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microbiological hydroxylation of aromatic acids
Assignee: Sunoco Inc
•
Filing: 1968-02-08
•
Granted: 1972-02-29
•
Expires: 1988-02-08
Abstract
Abstract A benzoic acid having from zero to three methyl and/or halo substituents and having at least two adjacent unsubstituted ring carbon atoms can be converted to the corresponding dihydroxybenzoic acid derivative by the action of various species of Nocardia which are normally incapable of performing such a conversion. This is accomplished by first contacting the Nocardia cells with an aromatic or halogenated aromatic hydrocarbon for a time sufficient to induce the enzyme system of said cells to perform such an hydroxylation, and thereafter contacting the induced cells with the benzoic acid substrate under aerobic conditions.
Inventors
- 👤 Robert W Eltz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:27
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P7/00; C12P7/40; C12P7/42; C12R; C12R2001/00; C12R2001/01; C12R2001/365; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/872
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
20 words
The process according to claim 1 wherein said fermentation conditions include a pH level of from about 5.5 to 9.5.
Claim 2
Dependent Claim
25 words
The process according to claim 1 wherein the induced species of Nocardia is a member of the species Nocardia corallina, Nocardia salmonicolor, or Nocardia minima.
Claim 3
Dependent Claim
30 words
The process according to claim 1 wherein the micro-organism is selected from the group consisting of ATCC No. 19,070; ATCC No. 19,071; ATCC No. 19,148; ATCC No. 19,149; and 19,150.
Claim 4
Dependent Claim
33 words
The process according to claim 1 wherein the benzoic acid is p-toluic acid, the inducer is biphenyl, the induced organism is Nocardia salmonicolor, ATCC No. 19,149, and the product recovered is 2,3-dihydroxy-p-toluic acid.
References Cited (Backward Citations)
US3383289A
Cited
US3458399A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-02-28 | 1975-08-30 | 1976-02-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-02-28 | 1979-08-30 | 1980-02-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-02-28 | 1983-08-30 | 1984-02-29 | $7700.00 | Window Closed / Lapsed |