US3671518A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzodiazepin-2-ones and processes for their preparation
Assignee: F Hoffmann La Roche AG
•
Filing: 1970-03-06
•
Granted: 1972-06-20
•
Expires: 1990-03-06
Abstract
Abstract 3-substituted benzodiazepin-2-ones, derivatives thereof and processes for their preparation are described. These compounds are useful as anti-convulsants, muscle relaxants and sedatives.
Inventors
- 👤 Joseph Hellerbach
- 👤 Andre Szente
- 👤 Armin Walser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:12
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; C07C; C07C271/00; C07C271/06; C07C271/08; C07C271/10; C07C271/22; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
19 words
A compound of claim 1 wherein the R1 substituent is selected from the group consisting of chlorine or nitro.
Claim 2
Dependent Claim
20 words
A compound of claim 1 wherein the R2 substituent is selected from the group consisting of chlorine, fluorine or hydrogen.
Claim 3
Dependent Claim
11 words
A compound of claim 1 wherein the R3 substituent is hydrogen.
Claim 4
Dependent Claim
21 words
A compound of claim 1 wherein the R4 substituent is selected from the group consisting of hydrogen, methyl or methoxy methyl.
Claim 5
Dependent Claim
21 words
A compound of claim 1 wherein the X substituent is selected from the group consisting of ethylene, propylene or the group
Claim 6
Dependent Claim
21 words
A compound of claim 1 wherein the R5 and R6 substituents are each methyl, ethyl, or taken together a morpholino group.
Claim 7
Dependent Claim
31 words
The compound of claim 1 wherein R1 is chlorine, R2 and R3 are hydrogen, R4 is methyl, R5 and R6 are each ethyl and X is propyl, i.e. 3-diethylaminopropyl 7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3 -carboxylate.
Claim 8
Dependent Claim
30 words
The compound of claim 1 wherein R1 and R2 are chlorine, R3 and R4 are hydrogen, R5 and R6 are each ethyl and X is propyl, i.e. 3-diethylaminopropyl 7-chloro-2,3-dihydro-2-oxo-5-(2-chlorophenyl)-1H-1,4-benzodiazepine-3 -carboxylate.
Claim 9
Dependent Claim
27 words
The compound of claim 1 wherein R1 is chlorine, R2, R3 and R4 are hydrogen, R5 and R6 are methyl, and X is methylpropyl, i.e. 2-(dimethylamino)-2-methylpropyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate.
Claim 10
Dependent Claim
28 words
The compound of claim 1 wherein R1 is nitro, R2, R3 and R4 are hydrogen, R5 and R6 are each ethyl and X is propyl, i.e. 3-diethylaminopropyl 2,3-dihydro-7-nitro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate.
Claim 11
Dependent Claim
29 words
The compound of claim 1 wherein R1 is chlorine, R2, R3 and R4 are hydrogen, R5 and R6 taken together are morpholino and X is ethyl, i.e. 2-morpholinoethyl 7-chloro-5-phenyl-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate.
Claim 12
Dependent Claim
33 words
The compound of claim 1 wherein R1 is nitro, R2 is chlorine, R3 is hydrogen, R4 is methyl, R5 and R6 taken together are morpholino, and X is propyl, i.e. 3-morpholinopropyl 7-nitro-5-(o-chlorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepine -3-carboxylate.
Claim 13
Dependent Claim
33 words
The compound of claim 1 wherein R1 is nitro, R2 is chlorine, R3 is hydrogen, R4 is methoxymethyl, R5 and R6 taken together are morpholino, and X is propyl, i.e. 3-morpholinopropyl 7-nitro-5-(o-chlorophenyl)-2,3-dihydro-1-methoxymethyl-2-oxo-1H-1,4 -benzodiazepine-3-carboxylate.
Claim 14
Dependent Claim
32 words
The compound of claim 1 wherein R1 is nitro, R2 is chlorine, R3 and R4 are hydrogen, R5 and R6 taken together are morpholino, and X is propyl, i.e. 3-morpholinopropyl 7-nitro-5-(o-chlorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3 -carboxylate.
Claim 15
Dependent Claim
5 words
A compound of the formula
References Cited (Backward Citations)
US3371085A
Cited
US3299053A
Cited
US3516988A
Cited
US3391138A
Cited
US3475415A
Cited
US3410844A
Cited
US3450695A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-06-20 | 1975-12-20 | 1976-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-06-20 | 1979-12-20 | 1980-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-06-20 | 1983-12-20 | 1984-06-20 | $7700.00 | Window Closed / Lapsed |