Novel thiazolyacetic acids and salts thereof

Abstract

Abstract R2-A-CH(-R3)-CO-R4'' WHEREIN R2 AND R3 HAVE THE SAME MEANINGS AS DEFINED ABOVE; R4'' IS THE SAME ALKOXY AS IN THE DEFINITION OF R4; AND A IS A GROUP OF THE FORMULA, -CO-CN(-X)- OR -CH(-X)-CO- WHEREIN X IS HALOGEN, TO YIELD AN ALKYL THIAZOLYLACETATE DERIVATIVE OF THE FORMULA, 2-R1,R2,(R4''-CO-CH(-R3)-)THIAZOLE WHEREIN R1, R2, R3 AND R4'' HAVE THE SAME MEANINGS AS DEFINED ABOVE, AND FURTHER, IF NECESSARY, CONTACTING THE RESULTANT ALKYL THIAZOLYLACETATE DERIVATIVE WITH A COMPOUND OF THE FORMULA, NOVEL THIAZOLYLACETIC ACID DERIVATIVES OF THE FORMULA, 2-R1,(R2),(R4-CO-CH(-R3)-)THIAZOLE R1-C(=S)-NH2 WHEREIN R1 HAS THE SAME MEANING AS DEFINED ABOVE, WITH A HALOGENATED COMPOUND OF THE FORMULA WHEREIN R1 IS PYRIDYL, UNSUBSTITUTED OR HALOGEN-, ALKYL-, ALKOXY-, PHENYL- OR HALOPHENYL-SUBSTITUTED INDOLYL, UNSUBSTITUTED OR HALOGEN-, NITRO-, METHYLENEDIOXY-, ALKYL- OR ALKOXY-SUBSTITUTED STYRYL; R2 IS HYDROGEN, ALKYL OR UNSUBSTITUTED OR SUBSTITUTED PHENYL; R3 IS HYDROGEN OR ALKYL; AND R4 IS HYDROXYL, ALKOXY, AMINO OR HYDRAZINO; AND SALTS THEREOF WHICH ARE USEFUL FOR ANTI-INFLAMMATORY AGENTS. THESE THIAZOLYLACETIC ACID DERIVATIVES ARE PRODUCED BY CONTACTING A THIOAMIDE DERIVATIVE OF THE FORMULA R4"-H WHEREIN R4" IS HYDROXYL, AMINO OR HYDRAZINO, TO YIELD A THIAZOLYLACETIC ACID DERIVATIVE OF THE FORMULA, 2-R1,R2,(R4"-CO-CH(-R3)-)THIAZOLE WHEREIN R1, R2, R3 AND R4" HAVE THE SAME MEANINGS AS DEFINED ABOVE.

Inventors

• 👤 Shin-Ichi Kaneko
• 👤 Kei Takahashi
• 👤 Hisao Yamamoto

Bibliographic Details