US3764616A
Expired / Lapsed
US
⏱️ 0.0 years remaining
21-phosphate esters of 17{60 -acyloxy-21 hydroxy steroids of the pregnane series
Assignee: Glaxo Laboratories Ltd
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Filing: 1969-10-14
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Granted: 1973-10-09
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Expires: 1989-10-14
Abstract
Abstract This invention is concerned with novel 21-phosphate esters of 17 Alpha -acyloxy-21-hydroxy steroids of the pregane series and with methods of preparing such compounds. The compounds are useful as topical anti-inflamatory agents.
Inventors
- 👤 J Elks
- 👤 P May
- 👤 G Phillipps
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57; A61K31/573; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0043; A61K9/0046; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2018; B; B23; B23D; B23D33/00; C; C07; C07J; C07J5/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
17 words
A compound as claimed in claim 1 in which the 16-methyl group is in the Beta -configuration.
Claim 2
Dependent Claim
12 words
A compound as claimed in claim 1 in which Y represents fluorine.
Claim 3
Dependent Claim
25 words
A compound as claimed in claim 1 in which R1 represents an alkanoyl group selected from the group consisting of butyryl, isobutyryl, valeryl and isovaleryl.
Claim 4
Dependent Claim
56 words
A compound as claimed in claim 1 selected from the group consisting of betamethasone 17-isobutyrate 21-dihydrogen phosphate; betamethasone 17-valerate 21-dihydrogen phosphate; 9 Alpha -chloro- 16 Beta -methylprednisolone 17-isobutyrate 21-dihydrogen phosphate; dexamethasone 17-isobutyrate 21-dihydrogen phosphate; betamethasone 17-acetate 21-dihydrogen phosphate; betamethasone 17-propionate 21-dihydrogen phosphate; betamethasone 17-butyrate 21-dihydrogen phosphate; betamethasone 17-benzoate 21-dihydrogen phosphate; and a non-toxic water-soluble salt thereof.
Claim 5
Dependent Claim
16 words
A compound as claimed in claim 1 in the form of its sodium or potassium salt.
References Cited (Backward Citations)
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Cited
US2789117A
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US2967179A
Cited
FR1365253A
Cited
US3064016A
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US3073816A
Cited
US3099654A
Cited
US3053834A
Cited
US3312590A
Cited
DE2022695A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-10-08 | 1977-04-09 | 1977-10-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-10-08 | 1981-04-09 | 1981-10-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-10-08 | 1985-04-09 | 1985-10-09 | $7700.00 | Window Closed / Lapsed |