Tricyclic ketonic compounds

Abstract

Abstract WHEREIN X IS HYDROGEN, HALOGEN OR TRIHALOIMETHYL, N'' IS 2 OR 3 AND A REPRESENTS THE REMAINDER OF A BENZENE RING OR ALSO, WHEN N'' IS 2, THE REMAINDER OF A THIOPHENE RING WHOSE SULFUR IS A TO THE CARBON ATOM ATTACHED TO THE KETONE CARBON ATOM SAID BENZENE RING OR SAID THIOPHENE RING BEING SUBSTITUTED IN A POSITION B TO THE CARBON ATOM ATTACHED TO THE KETONE CARBON ATOM BY AN ALKANOIC SUBSTITUENT HAVING THE FORMULA -CH(-Y)-(CH2)N-COO-Z WHERE Y IS HYDROGEN OR ALKYL HAVING 1 TO 3 CARBON ATOMS, N IS 0, 1 OR 3 AND Z IS HYDROGEN, LOWER ALKYL, LOWER HYDROXYALKYL, ACETONIDE OF LOWER HYDROXYALKYL, DI-LOWER ALKYLAMINO-LOWER ALKYL, N-HETEROCYCLIC-AMINOALKYL, ALKALI METAL OR ALKALI EARTH METAL, AND THE PROCESS OF PREPARATION. THESE TRICYCLIC KETONIC COMPOUNDS HAVE A CLEAR ANALGESIC ACTION AND A REMARKABLE ANTI-INFLAMMATORY ACTION WITHOUT A SECONDARY ULCERIGENIC EFFECT. POSSIBLY RACEMIC OR OPTICALLY ACTIVE TRICYCLIC KETONIC COMPOUNDS HAVING THE FORMULA O=C<(-(4-X-1,2-PHENYLENE)-(CH2)N''-C(=)-A-C(=)-) WHERE BOTH C''S ARE JOINED

Inventors

• 👤 A Allais
• 👤 L Nedelec
• 👤 J Guillaume
• 👤 D Frechet

Bibliographic Details