Secondary phosphoric acid esters and salts thereof

Abstract

Abstract 1. A NOVEL SECONDARY PHOSPHORIC ACID ESTER COMPOUND HAVING THE GENERAL FORMULA A-O-P(=O)(-O-M)-O-B WHEREIN M IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN: AND A PHARMACEUTICALLY ACCEPTABLE INORGANIC AND ORGANIC CATIONS; AND WHEREIN A IS R6,R7,R13-PHENYL- WHEREIN ONE AND ONLY ONE OF THE SUBSTITUENTS R6, R7, AND R13 ALWAYS REPRESENTS A GROUP R, LOCATED IN ANY OF THE ORTHO, META AND PARA POSITIONS RELATIVE TO THE PHOSPHORIC ACID ESTER GROUP, THE GROUP R HAVING THE FORMULA R3,R4,R5-PHENYL-X- WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF; -CO-(Z)Q-; -(Z)Q-CO-; WHEREIN Q IS SELECTED FROM THE GROUP CONSISTING OF ZERO AND ONE; AND WHEREIN Z IS SELECTED FROM THE GROUP CONSISTING OF: STRAIGHT SATURATED HYDROCARBON CHAINS HAVING AT MOST 3 CARBON ATOMS; AND STRAIGHT HYDROCARBON CHAINS HAVING 2 AND 3 CARBON ATOMS AND CONTAINING ONE DOUBLE BOND; Z ABOVE MAY BE SUBSTITUTED BY ONE SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF: LOWER ALKYL; LOWER ALKENYL; CYCLOPENTYL; CYCLOHEXYL; PHENYL; PHENYL SUBSTITUTED IN M- OR P-POSITION BY ONE SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, LOWER ALKOXY, -F,-CL, -BR, AND -CF3; BENZYL; BENZYL SUBSTITUTED IN M- OR P-POSITION BY ONE SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, LOWER ALKOXY, -F, -C1, -BR, AND -CF3; BENZYLIDENE; BENZYLIDENE SUBSTITUTED IN M- OR P-POSITION BY ONE SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, LOWER ALKOXY, -F, -CL, -BR, AND -CF3; WHEREIN B IN THE GENER FORMULA (I) ABOVE IS SELECTED FROM THE GROUP CONSISTING OF: ALKYL; HAVING ONE TO EIGHT CARBON ATOMS, INCLUSIVE, BEING AT MOST DI-SUBSTITUTED; CYCLOALKYL, NAMELY CYCLOPENTYL AND CYCLOHEXYL, BEING AT MOST DISUBSTITUTED; 1- AND 2-NAPHTHYL, BOTH NAPHTHYL BEING AT MOST DI-SUBSTITUTED: 2-, 3- AND 4-BIPHENYLYL, AND BIPHENYLYL BEING AT MOST DI-SUBSTITUTED; AND R10,R11,R12-PHENYL- WHEREIN THE SUBSTITUENTS IN B, WHEN B IS ALKYL, HAVING ONE TO EIGHT CARBON ATOMS, INCLUSIVE; CYCLOALKYL; NAPHTHYL; AND BIPHENYLYL, ARE SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, LOWER ALKOXY, -F, -CL, -BR, AND -CF3; WHEREIN SELECTED FROM THE GROUP CONSISTING OF; HYDROGEN; LOWER SELECTED FROM THE GROUP CONSISTING OF: HYDROGEN; LOWER ALKYL; LOWER ALKENYL; LOWER ALKOXY; HYDROXY; -O-CO-R14-; -F;-CL;-BR;-CF3; WHERE R14 IS LOWER ALKYL.

Inventors

• 👤 B Hogberg
• 👤 H Fex
• 👤 B Fredholm
• 👤 T Perklev
• 👤 S Veige

Bibliographic Details