US3855213A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-heterocyclic thiomethyl-cephalosporins
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1972-09-15
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Granted: 1974-12-17
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Expires: 1992-09-15
Abstract
Abstract Cephalosporin compounds substituted at the 7-position with free or substituted Alpha -amino or hydroxy phenylacetamido and at the 3-position with a heterocyclic thiomethyl group are prepared by displacement of a 3-acetoxy-methyl compound with a mercaptoheterocycle or by 7-acylation. The products are antibacterial agents.
Inventors
- 👤 G Dunn
- 👤 J Hoover
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:00
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/36; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K31/542; A61K31/545; C07D249/00; C07D249/02; C07D249/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
24 words
A compound as claimed in claim 1, in which R1 is triazolyl, unsubstituted or substituted with 1 or 2 lower alkyl groups or trifluoromethyl.
Claim 4
Dependent Claim
22 words
A compound as claimed in claim 2, in which R1 is 1,2,3-triazolyl, unsubstituted or substituted with 1 or 2 lower alkyl groups.
Claim 5
Dependent Claim
22 words
A compound as claimed in claim 2, in which R1 is 1,2,4-triazolyl, unsubstituted or substituted with 1 or 2 lower alkyl groups.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 3, being the compound 7-mandelamido-3-(1,2,3-triazol-4-ylthiomethyl)-3-cephem-4-carboxylic acid.
Claim 7
Dependent Claim
13 words
A compound as claimed in claim 4, being the compound 7-mandelamido-3-(4-methyl-1,2,4-triazol-3-ylthiomethyl)-3-cephem-4 -carboxylic acid.
Claim 8
Dependent Claim
13 words
A compound as claimed in claim 4, being the compound 7-mandelamido-3-(5-methyl-1,2,4-triazol-3-ylthiomethyl)-3-cephem-4 -carboxylic acid.
Claim 9
Dependent Claim
12 words
A compound as claimed in claim 4, being the coompound 7-mandelamido-3-(1,2,4-triazol-3-ylthiomethyl)-3-cephem-4-carboxylic acid.
Claim 10
Dependent Claim
13 words
A compound as claimed in claim 4, being the compound 7-mandelamido-3-(3,4-dimethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4 -carboxylic acid.
Claim 11
Dependent Claim
13 words
A compound as claimed in claim 3, being the compound 7-mandelamido-3-(4-methyl-1,2,3-triazol-5-ylthiomethyl)-3-cephem-4 -carboxylic acid.
Claim 12
Dependent Claim
17 words
A compound as claimed in claim 1, in which X and X1 are both other than hydrogen.
Claim 13
Dependent Claim
12 words
A compound as claimed in claim 4, being the compound 7-mandelamido-3-(1-methyl-1,2,4-triazol-3ylthiomethyl)-3-cephem-4-carboxylic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-16 | 1978-06-17 | 1978-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-16 | 1982-06-17 | 1982-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-16 | 1986-06-17 | 1986-12-17 | $7700.00 | Window Closed / Lapsed |