US3868457A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of inhibiting histamine activity with guanidine compounds
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1972-11-29
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Granted: 1975-02-25
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Expires: 1992-11-29
Abstract
Abstract A method of inhibiting histamine activity, in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.
Inventors
- 👤 James Whyte Black
- 👤 Graham John Durant
- 👤 John Colin Emmeti
- 👤 Charon Robin Ganellin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 14:25
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/28; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/36; C07D213/40; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/00; C07D233/04; C07D233/20; C07D233/24; C07D233/26; C07D233/54; C07D233/64; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
55 words
A METHOD OF INHIBITING H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECEPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDE, WHICH COMPRISES ADMINISTERING INTERNALLY TO AN ANIMAL REQUIRING INHIBITION OF SAID H-2 HISTAMINE RECPTORS IN AN AMOUNT SUFFICIENT TO INHIBIT SAID H-2 HISTAMINE RECEPTORS A COMPOUND OF THE FORMULA:
Claim 2
Independent Claim
55 words
A METHOD OF INHIBITING H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECEPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDE, WHICH COMPRISES ADMINISTERING INTERNALLY TO AN ANIMAL REQUIRING INHIBITION OF SAID H-2 HISTAMINE RECPTORS IN AN AMOUNT SUFFICIENT TO INHIBIT SAID H-2 HISTAMINE RECEPTORS A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
26 words
A method according to claim 1 in which A taken together with the carbon and nitrogen atoms to which it is attached forms an imidazol-4(5)-yl ring.
Claim 4
Dependent Claim
12 words
A method according to claim 1 in which the compound is 3-(4(5)-imidazolyl)propylguanidine.
Claim 5
Dependent Claim
12 words
A method according to claim 1 in which the compound is 5-(4(5)-imidazolyl)pentylguanidine.
Claim 6
Independent Claim
33 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal requiring inhibition of gastric acid secretion in an amount to inhibit gastric acid secretion a compound of the formula
Claim 7
Independent Claim
33 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal requiring inhibition of gastric acid secretion in an amount to inhibit gastric acid secretion a compound of the formula
Claim 8
Independent Claim
28 words
A method of producing anti-inflammatory activity which comprises administering to an animal requiring said activity in an amount sufficient to produce said activity a compound of the formula:
Claim 9
Independent Claim
28 words
A method of producing anti-inflammatory activity which comprises administering to an animal requiring said activity in an amount sufficient to produce said activity a compound of the formula:
References Cited (Backward Citations)
US3354174A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-24 | 1978-08-26 | 1979-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-24 | 1982-08-26 | 1983-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-24 | 1986-08-26 | 1987-02-25 | $7700.00 | Window Closed / Lapsed |