US3870466A
Expired / Lapsed
US
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Method and apparatus for automatic titration
Assignee: Mettler Toledo GmbH Germany
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Filing: 1973-01-15
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Granted: 1975-03-11
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Expires: 1993-01-15
Abstract
Abstract A method of, and apparatus for, automatic titration of a specimen to be tested, wherein means which causes a reaction with the specimen to be tested, such as a titrating agent or electrical charges for producing a reagent, is discontinuously supplied in individual amounts to the specimen. The variation in time in the value of a measurement parameter characterizing the condition of the specimen is determined. The respective next individual amount of said means is only supplied after the variation in time in the value of the measurement parameter has fallen below a predetermined value.
Inventors
- 👤 Werner Rellstab
- 👤 Hans Steiner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:35
CPC Classifications
G; G01; G01N; G01N31/00; G01N31/16; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/115831; Y10T436/116664
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
81 words
A METHOD FOR THE AUTOMATIC TITRATION OF A SPECIMEN TO BE TESTED, COMPRISING THE STEPS OF DISCONTINUOUSLY SUPPLYING IN INDIVIDUAL AMOUNTS TO THE SPECIMEN A CONSTITUENT WHICH CAUSES A REACTION WITH THE SPECIMEN, DETERMINING THE VARIATION IN TIME IN THE VALUE OF AN ELECTRICAL MEASUREMENT PARAMETER CHARACTERIZING THE CONDITION OF THE SPECIMEN, AND SUPPLYING A RESPECTIVE NEXT INDIVIDUAL AMOUNT OF SAID CONSTITUENT ONLY AFTER THE VARIATION IN TIME IN THE VALUE OF SAID ELECTRICAL MEASUREMENT PARAMETER HAS ENTERED A PRESELECTED RANGE.
Claim 2
Independent Claim
81 words
A METHOD FOR THE AUTOMATIC TITRATION OF A SPECIMEN TO BE TESTED, COMPRISING THE STEPS OF DISCONTINUOUSLY SUPPLYING IN INDIVIDUAL AMOUNTS TO THE SPECIMEN A CONSTITUENT WHICH CAUSES A REACTION WITH THE SPECIMEN, DETERMINING THE VARIATION IN TIME IN THE VALUE OF AN ELECTRICAL MEASUREMENT PARAMETER CHARACTERIZING THE CONDITION OF THE SPECIMEN, AND SUPPLYING A RESPECTIVE NEXT INDIVIDUAL AMOUNT OF SAID CONSTITUENT ONLY AFTER THE VARIATION IN TIME IN THE VALUE OF SAID ELECTRICAL MEASUREMENT PARAMETER HAS ENTERED A PRESELECTED RANGE.
Claim 3
Independent Claim
81 words
A method for the automatic titration of a specimen to be tested, comprising the steps of discontinuously supplying in individual amounts to the specimen a constituent which causes a reaction with the specimen, determining the variation in time in the value of an electrical measurement parameter characterizing the condition of the specimen, and supplying a respective next individual amount of said constituent only after the variation in time in the value of said electrical measurement parameter has entered a preselected range.
Claim 4
Independent Claim
81 words
A method for the automatic titration of a specimen to be tested, comprising the steps of discontinuously supplying in individual amounts to the specimen a constituent which causes a reaction with the specimen, determining the variation in time in the value of an electrical measurement parameter characterizing the condition of the specimen, and supplying a respective next individual amount of said constituent only after the variation in time in the value of said electrical measurement parameter has entered a preselected range.
Claim 5
Dependent Claim
23 words
The method as defined in claim 1, including the step of discontinuously supplying in individual amounts a titrating agent serving as said constituent.
Claim 6
Dependent Claim
28 words
The method as defined in claim 2, including the step of discontinuously supplying the titrating agent in equal individual amounts at least over part of the titration operation.
Claim 7
Dependent Claim
24 words
The method as defined in claim 3, further including the step of adjusting the size of the equal individual amounts of the titrating agent.
Claim 8
Dependent Claim
13 words
The method as defined in claim 1, wherein the preselected range is adjustable.
Claim 9
Dependent Claim
29 words
The method as defined in claim 1, including the step of setting a predetermined time delay in order to take into account the response time of the measuring system.
Claim 10
Dependent Claim
39 words
The method as defined in claim 2, further including the step of visually displaying the respective value of the electrical measurement parameter prior to the commencement of each operation of supplying each said individual amount of said titrating agent.
Claim 11
Dependent Claim
101 words
The method as defined in claim 7, further including the step of visually displaying the respective value of the electrical measurement parameter only after at least one time interval has passed since the preceding supply of one said individual amount, the length of said time interval being governed by the maximum value of the particular variation in time in the value of the electrical measurement parameter, but not falling below a given minimum value, and its number being determined by the frequency with which the variation in time of the value of the electrical measurement parameter passes through said preselected region.
Claim 12
Dependent Claim
33 words
The method as defined in claim 7, further including the step of automatically preventing display of an electrical measurement parameter value upon premature termination of the supply of titrating agent to the specimen.
Claim 13
Dependent Claim
34 words
The method as defined in claim 2, further including the step of registering the respective value of the electrical measurement parameter prior to the commencement of each operation of supplying each said individual amount.
Claim 14
Dependent Claim
99 words
The method as defined in claim 10, wherein the registration of the respective value of the electrical measurement parameter occurs only after at least one time interval has passed since the preceding supply of one said individual amount, the length of said time interval being governed by the maximum value of the particular variation in time in the value of the electrical measurement parameTer, but not falling below a given minimum value, and its number being determined by the frequency with which the variation in time of the value of the electrical measurement parameter passes through said preselected region.
Claim 15
Dependent Claim
33 words
The method as defined in claim 10, further including the step of automatically preventing registration of the electrical measurement parameter value upon premature termination of the supply of titrating agent to the specimen.
Claim 16
Independent Claim
121 words
An apparatus for the automatic titration of a specimen to be tested, comprising a reaction vessel for the specimen and having at least one measuring sensing means, means for discontinuously supplying individual amounts of a titrating agent to the specimen, a measuring amplifier for amplification of the value of an electrical measurement parameter characterizing the condition of the specimen, means for forming the first differential in time of the electrical measurement parameter, means for controlling the supply of titrating agent, said controlling means incorporating means for comparing the variation in time in the value of the electrical measurement parameter with a preselected range, and means imparting a supply command to said supply means after said variation has entered said preselected range.
Claim 17
Independent Claim
121 words
An apparatus for the automatic titration of a specimen to be tested, comprising a reaction vessel for the specimen and having at least one measuring sensing means, means for discontinuously supplying individual amounts of a titrating agent to the specimen, a measuring amplifier for amplification of the value of an electrical measurement parameter characterizing the condition of the specimen, means for forming the first differential in time of the electrical measurement parameter, means for controlling the supply of titrating agent, said controlling means incorporating means for comparing the variation in time in the value of the electrical measurement parameter with a preselected range, and means imparting a supply command to said supply means after said variation has entered said preselected range.
Claim 18
Dependent Claim
15 words
The apparatus as defined in claim 13, further including means for setting said preselected range.
Claim 19
Dependent Claim
24 words
The apparatus as defined in claim 13, further including means for setting the size of the individual amounts of the supply of titrating agent.
Claim 20
Dependent Claim
20 words
The apparatus as defined in claim 13, further including means for selectively time delaying a response time of the apparatus.
Claim 21
Dependent Claim
34 words
The apparatus as defined in claim 13, further including means for visually displaying a respective value of the electrical measurement parameter before the beginning of the supply of each individual amount of titrating agent.
Claim 22
Dependent Claim
47 words
The apparatus as defined in claim 17, further including means for producing at least one variable time interval between the first variation in the value of the electrical measurement parameter falling below the preselected range and the indication of the respective value of the electrical measurement parameter.
Claim 23
Dependent Claim
35 words
The apparatus as defined in claim 17, further including means for automatically preventing further display of the value of the electrical measurement parameter when the supply of titrating agent to the specimen is prematurely terminated.
Claim 24
Dependent Claim
33 words
The apparatus as defined in claim 13, further including means for registering a respective value of the electrical measurement parameter before the beginning of the supply of each individual amount of titrating agent.
Claim 25
Dependent Claim
47 words
The apparatus as defined in claim 20, further including means for producing at least one variable time interval between the first variation in the value of the electrical measurement parameter falling below the preselected range and the registration of the respective value of the electrical measurement parameter.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-10 | 1978-09-09 | 1979-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-10 | 1982-09-09 | 1983-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-10 | 1986-09-09 | 1987-03-11 | $7700.00 | Window Closed / Lapsed |