US3873600A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenoxycarbamates
Assignee: Individual
•
Filing: 1973-03-19
•
Granted: 1975-03-25
•
Expires: 1993-03-19
Abstract
Abstract AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R'' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'''', -SR'''', and -NHCOOR'''', R'''' being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the Beta -receptors of the heart making them useful in treating heart diseases in animals including humans. Para-substituted phenoxy-hydroxypropylamines having the general formula
Inventors
- 👤 Arne Elof Brandstrom
- 👤 Per Arvid Emil Carlsson
- 👤 Stig Ake Ingemar Carlsson
- 👤 Hans Rudolf Corrodi
- 👤 Lars Ek
- 👤 Bengt Arne Hjalmar Ablad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; A61K31/21; A61K31/27; A61P; A61P25/00; A61P25/02; A61P9/00; C; C07; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/28; C07C217/30; C07C217/32; C07C233/00; C07C233/01; C07C233/16; C07C233/17; C07C233/22; C07C317/00; C07C317/02; C07C317/10; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07D; C07D263/00; C07D263/02; C07D263/08; C07D263/16; C07D263/18; C07D263/20; C07D263/24; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/24; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
3 words
A COMPOUND FORMULA
Claim 2
Dependent Claim
3 words
A COMPOUND FORMULA
Claim 3
Dependent Claim
17 words
A compound according to claim 1 in racemic form and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 4
Dependent Claim
22 words
A compound levo-rotatory to claim 1 in optically active form, as the levo-rotary antipode and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 5
Dependent Claim
22 words
A compound according to claim 1 in optically active form, as the dextro-rotatory antipode and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein R'' is isopropyl.
Claim 7
Dependent Claim
18 words
The compound of claim 1 ( + or - )-1-isopropylamino-3-(p-methoxycarbonylaminoethyl)-phenoxy)-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 8
Dependent Claim
17 words
The compound of the claim 1 (-)-1-isopropylamino-3-(p-( Beta -methoxycarbonylaminoethyl-phenoxyl)-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 9
Dependent Claim
14 words
The compound of claim 1 (+)-1-isopropylamino-3-(p-methoxycarbonylaminoethyl)-phenoxy)-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 10
Dependent Claim
16 words
The compound of claim 1, 1-isopropylamino-3-(p-( gamma -methoxycarbonylaminopropyl)-phenoxy)-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 11
Dependent Claim
8 words
The compound of claim 1 wherein R''is tertiary.-butyl.
Claim 12
Dependent Claim
15 words
The compound of claim 1, 1-tert.-butylamino-3-(p-( Beta -methoxycarbonyluminoethyl)-phenoxy)-propanol-2and pharmaceutically acceptable, non-toxic acid addition salts thereof.
References Cited (Backward Citations)
US3712927A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-24 | 1978-09-23 | 1979-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-24 | 1982-09-23 | 1983-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-24 | 1986-09-23 | 1987-03-25 | $7700.00 | Window Closed / Lapsed |