US3883569A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel 3{60 -hydroxysteroids of the 5{60 -pregnane series
Assignee: Glaxo Laboratories Ltd
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Filing: 1971-12-16
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Granted: 1975-05-13
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Expires: 1991-12-16
Abstract
Abstract Steroids of the 5 Alpha -pregnane series possessing a 3 Alpha hydroxy group, a 10-hydrogen atom or methyl group, an 11-oxo group, a 17 Alpha -hydrogen atom, a 20-oxo group, and a group of the formula -XR at the 21-position wherein -XR represents -OCOR, -OCOOR, -CCOSR or -OCONHR and R represents (a) a solubilising group containing a basic nitrogen atom, (b) a nitrobenzyl group (c) a lower alkyl group (when X is not -OCO-) or (d) a halogenoalkyl group. The steroids possess anaesthetic properties.
Inventors
- 👤 Gordon Hanley Phillipps
- 👤 Christopher Earle Newall
- 👤 Martin Christopher Cook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:12
CPC Classifications
C; C07; C07J; C07J5/00; C07J43/00; C07J43/003
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
146 words
A STEROID OF THE 5A-PREGNANE SERIES POSSESSING A 3AHYDROXY GROUP, A 10-HYDROGEN OR METHYL GROUP, AND 11-OXO GRPI THE FORMULA -XR AT THE 21-POSITION, WHEREIN X REPRESENTS A GROUP OF THE FORMULA -OCO- OR -OCOO- AND R REPRESENTS: A. AN ALKYL GROUP OF 1-5 CARBON ATOMS OR BENZYL GROUP, EACH OF SAID ALKYL OR BENZYL GROUPS BEING SUBSTITUTED BY A GROUP OF THE FORMULA -NR 1R2 WHEREIN R1 AND R2 ARE THE SAME OR DIFFERENT AND EACH REPRESENTS A HYDROGEN ATOM OR AN ALKYL GROUP HAVING 1-4 CARBON ATOMS OR WHEREIN R1 AND R2 TOGETHER WITH THE NITROGEN ATOM REPRESENT A PIPERAZINO OR MORPHOLINO GROUP OR SUCH A GROUP SUBSTITUTED BY AT LEAST ONE ALKYL GROUP CONTAINING 1-6 CARBON ATOMS, OR A PYRIDYL GROUP, B. A NITROBENZYL GROUP WHEN X IS -OCO-, OR C. A LOWER ALKYL GROUP CONTAINING 1-5 CARBON ATOMS WHEN X IS -OCOO-.
Claim 2
Dependent Claim
146 words
A STEROID OF THE 5A-PREGNANE SERIES POSSESSING A 3AHYDROXY GROUP, A 10-HYDROGEN OR METHYL GROUP, AND 11-OXO GRPI THE FORMULA -XR AT THE 21-POSITION, WHEREIN X REPRESENTS A GROUP OF THE FORMULA -OCO- OR -OCOO- AND R REPRESENTS: A. AN ALKYL GROUP OF 1-5 CARBON ATOMS OR BENZYL GROUP, EACH OF SAID ALKYL OR BENZYL GROUPS BEING SUBSTITUTED BY A GROUP OF THE FORMULA -NR 1R2 WHEREIN R1 AND R2 ARE THE SAME OR DIFFERENT AND EACH REPRESENTS A HYDROGEN ATOM OR AN ALKYL GROUP HAVING 1-4 CARBON ATOMS OR WHEREIN R1 AND R2 TOGETHER WITH THE NITROGEN ATOM REPRESENT A PIPERAZINO OR MORPHOLINO GROUP OR SUCH A GROUP SUBSTITUTED BY AT LEAST ONE ALKYL GROUP CONTAINING 1-6 CARBON ATOMS, OR A PYRIDYL GROUP, B. A NITROBENZYL GROUP WHEN X IS -OCO-, OR C. A LOWER ALKYL GROUP CONTAINING 1-5 CARBON ATOMS WHEN X IS -OCOO-.
Claim 3
Dependent Claim
13 words
A steroid as claimed in claim 1 wherein XR is an -OCOR group.
Claim 4
Dependent Claim
16 words
The steroid of claim 1 which possesses at the 2 Beta -position a lower alkoxy group.
Claim 5
Dependent Claim
26 words
A steroid as claimed in claim 1 wherein the group -NR'' R2 is an unsubstituted amino group or a dimethylamino, a diethylamino, or a morpholino group.
Claim 6
Dependent Claim
21 words
A steroid as claimed in claim 1 in the form of the salt of the steroid with a physiologically compatible acid.
Claim 7
Dependent Claim
7 words
21-Diethylaminoacetoxy-3 Alpha -hydroxy-2 Beta -methoxy-5 Alpha -pregnane-11,20-dione.
Claim 8
Dependent Claim
7 words
21-Diethylaminoacetoxy-3 Alpha -hydroxy-2 Beta -methoxy-5 Alpha -pregnane-11,20-dione.
Claim 9
Dependent Claim
6 words
21-Aminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11,20-dione hydrochloride.
Claim 10
Dependent Claim
6 words
21-Aminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11,20-dione hydrochloride.
Claim 11
Dependent Claim
6 words
21-Diethylaminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 12
Dependent Claim
6 words
21-Diethylaminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 13
Dependent Claim
5 words
21-Dimethylaminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11,20-dione.
Claim 14
Dependent Claim
5 words
21-Dimethylaminoacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11,20-dione.
Claim 15
Dependent Claim
6 words
21-Aminophenylacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 16
Dependent Claim
6 words
21-Aminophenylacetoxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 17
Dependent Claim
6 words
21-Ethoxycarbonyloxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 18
Dependent Claim
6 words
21-Ethoxycarbonyloxy-3 Alpha -hydroxy-5 Alpha -pregnane-11, 20-dione.
Claim 19
Dependent Claim
5 words
A steroid of the formula:
Claim 20
Dependent Claim
5 words
A steroid of the formula:
References Cited (Backward Citations)
US3714352A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-12 | 1978-11-11 | 1979-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-12 | 1982-11-11 | 1983-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-12 | 1986-11-11 | 1987-05-13 | $7700.00 | Window Closed / Lapsed |