3-Chloro-tetrahydro-1,3-oxazines or oxazolidines

Abstract

Abstract There is provided, novel 3-chlorotetrahydro-1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: WHEREIN EACH OF R1 and R2, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C1-C5 being preferred); wherein each of R5 and R6, which may be the same or different, represent a hydrogen atom or an alkyl group of from 1 to 20 carbon atoms (C1-C5 being preferred); wherein l represents an integer of 1 or 2 and wherein each of R3 and R4, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C1-C5 being preferred), a -(CH2)nX group, wherein n represents an integer of from 1 to 20 and wherein X represents a dimethylamino group, a diethylamino group, a trimethylammonium group, a triethylammonium group, a dimethylammonium group, a diethylammonium group, a -COOR7 group, a -OOCR8 group, and a -OR9 group, wherein each of R7 through R9, respectively, represent an alkyl group of from 1 to 5 carbon atoms or a benzyl group. In addition, R3 and R4 can also represent a group, wherein Y represents a -(CH2)n-W-(CH2)m- group or a >CH-Z group, wherein W represents a -O- atom, a -CH2- group, a >NCH3group, a >NHCH3 group, a >NC2H5 group, a >NHC2H5 group, a >N(CH3)2 group, or a >N(C2H5)2 group, wherein n is the same or different from m and wherein each of n and m represent an integer of from 0 to 2; and wherein Z is defined in accordance with X above.

Inventors

• 👤 Nicolae S Bodor
• 👤 James J Kaminski

Bibliographic Details