US3898329A
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Vasoactive intestinal peptide, composition and method
Assignee: Research Corp
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Filing: 1973-11-20
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Granted: 1975-08-05
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Expires: 1993-11-20
Abstract
Abstract A method for producing therapeutic biological actions including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, hyperglycemia, coronary dilation and bronchodilation in animals and humans by treatment with a vasoactive intestinal polypeptide, V.I.P., which exhibits the following amino acid sequence: L-His-L-Ser-L-Asp-L-Ala-L-Val-L-Phe-L-Thr-L-Asp-L-Asn-L-Tyr-LThr-L-Arg-L-Leu-L-Arg-L-Lys-L-Gln-L-Met-L-Ala-L-Val-L-Lys-L-LysL-Tyr-L-Leu-L-Asn-L-Ser-L -Ile-L-Leu-L-Asn-NH2 Therapeutic biological actions may be produced in animals and humans by intravenous injection by 0.02-10 Mu g of V.I.P. per kg of body weight. V.I.P. may also be administered by other methods which usually is dictated by the area of use. Also provided are novel compositions for use in method.
Inventors
- 👤 Sami I Said
- 👤 Viktor Mutt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:14
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/57563; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/17
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
20 words
A THERAPEUTIC COMPOSITION COMPRISING ABOUT 0.001 TO 0.1 WEIGHT PERCENT OF THE POLYPEPTIDE, V.I.P., HAVING THE FOLLOWING AMINO ACID SEQUENCE:
Claim 2
Dependent Claim
20 words
A THERAPEUTIC COMPOSITION COMPRISING ABOUT 0.001 TO 0.1 WEIGHT PERCENT OF THE POLYPEPTIDE, V.I.P., HAVING THE FOLLOWING AMINO ACID SEQUENCE:
Claim 3
Independent Claim
35 words
A method for producing cardiovascular, respiratory, metabolic and smooth muscle-relaxant biological actions in animals and humans comprising administering thereto a therapeutically effective amount of the polypeptide V.I.P. having the following amino acid sequence: L-His-L-Ser-L-Asp-L-Ala-L-Val-L-Phe-L-Thr-L-Asp-L-Asn-L-Tyr-L-Thr-L-Arg-L -Leu-L-Arg-L-Lys-L-Gln-L-Met-L-Ala-L-Val-L-Lys-L-Lys-L-Tyr-L-Leu-L-Asn-L-Ser-L-Ile-L-Leu-L-Asn-NH2.
Claim 4
Independent Claim
35 words
A method for producing cardiovascular, respiratory, metabolic and smooth muscle-relaxant biological actions in animals and humans comprising administering thereto a therapeutically effective amount of the polypeptide V.I.P. having the following amino acid sequence: L-His-L-Ser-L-Asp-L-Ala-L-Val-L-Phe-L-Thr-L-Asp-L-Asn-L-Tyr-L-Thr-L-Arg-L -Leu-L-Arg-L-Lys-L-Gln-L-Met-L-Ala-L-Val-L-Lys-L-Lys-L-Tyr-L-Leu-L-Asn-L-Ser-L-Ile-L-Leu-L-Asn-NH2.
Claim 5
Dependent Claim
23 words
A method according to claim 2 wherein about 0.02 to 10 Mu g of the V.I.P. per kg of body weight is administered.
Claim 6
Dependent Claim
17 words
A method according to claim 3 wherein the V.I.P. is in combination with a physiologically acceptable carrier.
Claim 7
Dependent Claim
12 words
A method according to claim 3 wherein administration is by intravenous injection.
Claim 8
Dependent Claim
19 words
A method according to claim 4 wherein the carrier is a normal saline sOlution or a solution of Tris(hydroxymethyl)amino-methane.
Claim 9
Dependent Claim
16 words
A method according to claim 2 wherein the biological action is systemic, pulmonary or splanchnic vasodilation.
Claim 10
Dependent Claim
12 words
A method according to claim 2 wherein the biological action is hypotension.
Claim 11
Dependent Claim
14 words
A method according to claim 2 wherein the biological action is increased cardiac output.
Claim 12
Dependent Claim
13 words
A method according to claim 2 wherein the biological action is respiratory stimulation.
Claim 13
Dependent Claim
12 words
A method according to claim 2 wherein the biological action is hyperglycemia.
Claim 14
Dependent Claim
12 words
A method according to claim 2 wherein the biological action is bronchodilation.
Claim 15
Dependent Claim
13 words
A method according to claim 12 wherein the V.I.P. is administered by inhalation.
Claim 16
Dependent Claim
19 words
A method according to claim 2 wherein the biological action is coronary dilation and the V.I.P. is administered sublingually.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-04 | 1979-02-03 | 1979-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-04 | 1983-02-03 | 1983-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-04 | 1987-02-03 | 1987-08-05 | $7700.00 | Window Closed / Lapsed |