US3907771A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotic 66-40
Assignee: Merck Sharp & Dohme LLC
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Filing: 1973-06-25
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Granted: 1975-09-23
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Expires: 1993-06-25
Abstract
Abstract Antibiotic 66-40, a new broad spectrum antibiotic having an adverse effect upon the growth of gram-positive and gram-negative bacteria, is described together with its method of production via the fermentation of Micromonospora inyoensis, a new species of Micromonospora.
Inventors
- 👤 Marvin J Weinstein
- 👤 George M Luedemann
- 👤 Gerald H Wagman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 01:19
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/863
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
109 words
A MEMBER SELECTED FROM THE GROUP CONSISTING OF SISOMICIN, NON-TOXIC ACID ADDITION SALTS, INCLUDING SOLVATES THEREOF, AND CONDENSATION PRODUCTS OF SISOMICIN WITHALDEHYDES HAVING UP TO 12 CARBON ATOMS, SAID SISOMICIN BEING A SOLID COMPOSITION OF MATTER HAVING: A. A MOLECULAR WEIGHT OF 447.26 AS DETERMINED BY MASS SPECTROMETRY, B. THE EMPIRICAL FORMULA C19H37N5O7, C. A SPECIFIC OPTICAL ROTATION AS MEASURED BY THE D LINE OF SODIUM AT 26* OF +188.9* IN WATER AT 0.3% CONCENTRATION, D. AN INFRARED ABSORPTION SPECTRUM IN MINERAL OIL SUBSTANTIALLY AS SHOWN IN FIG. 1, AND E. A NUCLEAR MAGNETIC SPECTRUM IN DEUTERIUM OXIDE AS SHOWN IN FIG 2: SAID SISOMICIN HAVING THE FOLLOWING FORMULA:
Claim 2
Dependent Claim
109 words
A MEMBER SELECTED FROM THE GROUP CONSISTING OF SISOMICIN, NON-TOXIC ACID ADDITION SALTS, INCLUDING SOLVATES THEREOF, AND CONDENSATION PRODUCTS OF SISOMICIN WITHALDEHYDES HAVING UP TO 12 CARBON ATOMS, SAID SISOMICIN BEING A SOLID COMPOSITION OF MATTER HAVING: A. A MOLECULAR WEIGHT OF 447.26 AS DETERMINED BY MASS SPECTROMETRY, B. THE EMPIRICAL FORMULA C19H37N5O7, C. A SPECIFIC OPTICAL ROTATION AS MEASURED BY THE D LINE OF SODIUM AT 26* OF +188.9* IN WATER AT 0.3% CONCENTRATION, D. AN INFRARED ABSORPTION SPECTRUM IN MINERAL OIL SUBSTANTIALLY AS SHOWN IN FIG. 1, AND E. A NUCLEAR MAGNETIC SPECTRUM IN DEUTERIUM OXIDE AS SHOWN IN FIG 2: SAID SISOMICIN HAVING THE FOLLOWING FORMULA:
Claim 3
Dependent Claim
16 words
A compound of claim 1, said compound being sisomicin monohydrate in its essentially pure crystalline form.
Claim 4
Dependent Claim
9 words
A compound of claim 1, said compound being sisomicin.
Claim 5
Dependent Claim
15 words
A compound of claim 1, said compound being a nontoxic acid addition salt of sisomicin.
Claim 6
Dependent Claim
10 words
A compound of claim 4, said compound being sisomicin hydrochloride.
Claim 7
Dependent Claim
10 words
A compound of claim 4, said compound being sisomicin sulfate.
Claim 8
Dependent Claim
8 words
A compound of claim 1 of the formula:
Claim 9
Dependent Claim
16 words
A compound of claim 7 wherein R1R2C is a benzylidene radical, said compound having the formula:
References Cited (Backward Citations)
US3651042A
Cited
US3753973A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |