US3922145A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypothyroid serum control
Assignee: Warner Lambert Co LLC
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Filing: 1974-05-28
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Granted: 1975-11-25
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Expires: 1994-05-28
Abstract
Abstract Described is the preparation of a hypothyroid serum control using normal serum and serum containing elevated levels of thyroxine binding globulin. The control serum exhibits hypothyroid values in clinical tests that measure triiodothyronine uptake and thyroxine concentration.
Inventors
- 👤 James E Turner
- 👤 Michael B Kenoff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:47
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N33/74; G01N33/78; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/106664; Y10T436/107497
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
78 words
A METHOD FOR OBTAINING A HYPOTHYROID SERUM CONTROL COMPRISING THE FOLLOWING STEPS: A. ADDING NEUTRA, DECOLORIZING CARBON TO BLOOD SERUM IN AN AMOUNT OF ABOUT 5-20 PERCENT BASED UPON WEIGHT OF CARBON TO VOLUME OF SERUM; B. MIXING THE ABOVE MIXTURE FOR ABOUT 24 HOURS AT A TEMPERATURE OF ABOUT 4*C; C. TWICE CENTRIFUGING THE RESULTING SLURRY AT 34,800 XG AND AT A TEMPERATURE OF ABOUT 4*C; D. FILTERING THE RESULTANT SUPERNATANT; E. LYOPHILIZING THE SUPERNATANT SO OBTAINED.
Claim 2
Independent Claim
78 words
A METHOD FOR OBTAINING A HYPOTHYROID SERUM CONTROL COMPRISING THE FOLLOWING STEPS: A. ADDING NEUTRA, DECOLORIZING CARBON TO BLOOD SERUM IN AN AMOUNT OF ABOUT 5-20 PERCENT BASED UPON WEIGHT OF CARBON TO VOLUME OF SERUM; B. MIXING THE ABOVE MIXTURE FOR ABOUT 24 HOURS AT A TEMPERATURE OF ABOUT 4*C; C. TWICE CENTRIFUGING THE RESULTING SLURRY AT 34,800 XG AND AT A TEMPERATURE OF ABOUT 4*C; D. FILTERING THE RESULTANT SUPERNATANT; E. LYOPHILIZING THE SUPERNATANT SO OBTAINED.
Claim 3
Dependent Claim
35 words
The method of claim 1 which includes adding untreated normal serum in an amount of about 10 to about 35 percent of the serum volume of step A to the filtered supernatant of step D.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the serum is animal blood serum.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the serum is human blood serum.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein the serum is beef blood serum.
Claim 7
Dependent Claim
17 words
The method of claim 4 wherein the serum is T4-euthyroid, hypothyroid, or hyperthyroid and T3-euthyroid or hypothyroid.
Claim 8
Dependent Claim
10 words
The method of claim 6 wherein the serum is T3-hypothyroid.
Claim 9
Dependent Claim
12 words
The method of claim 6 wherein the serum is T4-euthyroid and T3-euthyroid.
Claim 10
Dependent Claim
28 words
A control serum judged hypothyroid by methods which measure T4 concentration and T3 uptake comprising blood serum which has been treated by the method according to claim 1.
Claim 11
Dependent Claim
44 words
In clinical chemistry procedures for measuring a person''s serum triiodothyronine uptake level and thyroxine concentration, the Improvement of which comprises the use of a single control serum standard which is a hypothyroid reference control serum for both triiodothyronine uptake level and thyroxine concentration tests.
Claim 12
Dependent Claim
44 words
In clinical chemistry procedures for measuring a person''s serum triiodothyronine uptake level and thyroxine concentration, the Improvement of which comprises the use of a single control serum standard which is a hypothyroid reference control serum for both triiodothyronine uptake level and thyroxine concentration tests.
Claim 13
Dependent Claim
79 words
The improvement of claim 10 in which the hypothyroid reference control serum preparation comprises the following steps: A. adding neutral, decolorizing carbon to blood serum in an amount of about 5-20 percent based upon weight of carbon to volume of serum; B. mixing the above mixture at a temperature of about 4*C; C. twice centrifuging the resulting slurry at 34,800 g and at a temperature of about 4*C; D. filtering the resultant supernatant; E. lyophilizing the supernatant so obtained.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-24 | 1979-05-26 | 1979-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-24 | 1983-05-26 | 1983-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-24 | 1987-05-26 | 1987-11-25 | $7700.00 | Window Closed / Lapsed |