US3922379A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microencapsulation process
Assignee: Abbott Laboratories
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Filing: 1973-12-17
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Granted: 1975-11-25
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Expires: 1993-12-17
Abstract
Abstract The process of the present invention is designed to protect particles of substantially water-insoluble, pharmaceutically active, erythromycin derivatives from being inactivated by the acids of the stomach and simultaneously to cover their objectionable taste. Small particles of the drug are encapsulated in a water-soluble albumin which is then coagulated to form a protective water-insoluble coating essentially around each of the drug particles. The new particles are particularly suitable for processing into chewable tablets, suspensions, syrups or other dosage unit forms for oral administration.
Inventors
- 👤 Bahram Farhadieh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5052; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/0087; A61K9/0095; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
99 words
THE PROCESS OF PREPARING ESSENTIALLY TASTELESS PARTICLES OF AN ORALLY ACTIVE DERIVATIVE OF ERYTHROMYCIN, CONSISTING ESSENTIALLY IN SUSPENDING PARTICLES OF 10 - 150 MICRONS DIAMETER OF SAID ERYTHROMYCIN DERIVATIVE IN WATER ADJUSTED TO A PH ABOVE 7.0, CONTAINING OR DISSOLVING THEREIN A WATER-SOLUBLE PROTEIN, WHICH IS HEAT COAGULABLE AT A TEMPERATURE BETWEEN 50* AND 80* C., STIRRING SAID SUSPENSION INTO A LIQUID ALKANE CONTAINING 1 10% BY WEIGHT OF A NONIONIC SURFACTANT, EMULSIFYING THE MIXTURE, HEATING SAID MIXTURE UNDER STIRRING FOR A PERIOD SUFFICIENT TO CAGULATE SAID HEAT COAGULABLE PROTEIN, AND COLLECTING THE COATED PARTICLES SOLID FROM SAID SUSPENSION.
Claim 2
Dependent Claim
99 words
THE PROCESS OF PREPARING ESSENTIALLY TASTELESS PARTICLES OF AN ORALLY ACTIVE DERIVATIVE OF ERYTHROMYCIN, CONSISTING ESSENTIALLY IN SUSPENDING PARTICLES OF 10 - 150 MICRONS DIAMETER OF SAID ERYTHROMYCIN DERIVATIVE IN WATER ADJUSTED TO A PH ABOVE 7.0, CONTAINING OR DISSOLVING THEREIN A WATER-SOLUBLE PROTEIN, WHICH IS HEAT COAGULABLE AT A TEMPERATURE BETWEEN 50* AND 80* C., STIRRING SAID SUSPENSION INTO A LIQUID ALKANE CONTAINING 1 10% BY WEIGHT OF A NONIONIC SURFACTANT, EMULSIFYING THE MIXTURE, HEATING SAID MIXTURE UNDER STIRRING FOR A PERIOD SUFFICIENT TO CAGULATE SAID HEAT COAGULABLE PROTEIN, AND COLLECTING THE COATED PARTICLES SOLID FROM SAID SUSPENSION.
Claim 3
Dependent Claim
11 words
The process of claim 1 wherein said liquid alkane is isooctane.
Claim 4
Dependent Claim
11 words
The process of claim 1 wherein said protein is egg albumin.
Claim 5
Dependent Claim
13 words
The process of claim 1 wherein said pH is between 7.5 and 8.5.
Claim 6
Dependent Claim
12 words
The process of claim 1 wherein said surfactant is a sorbitan trioleate.
Claim 7
Dependent Claim
23 words
The process of claim 1 wherein said albumin and said erythromycin derivative are present in a weight ratio of between 1:2 and 2:1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-24 | 1979-05-26 | 1979-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-24 | 1983-05-26 | 1983-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-24 | 1987-05-26 | 1987-11-25 | $7700.00 | Window Closed / Lapsed |