US3933802A
Expired / Lapsed
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New sulphamoylbenzoic acid amides
Assignee: Novartis Corp
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Filing: 1974-05-22
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Granted: 1976-01-20
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Expires: 1994-05-22
Abstract
Abstract New 2-amino-5-sulphamoylbenzoic acid amide of the general formula ##SPC1## Wherein R 1 denotes lower alkyl, R 2 denotes hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, R 3 denotes hydrogen, hydroxyl or lower alkyl, R 4 denotes acyl and alk denotes lower 1,2-alkylene or 1,3-alkylene or a therapeutically acceptable acid addition salt thereof are usefull as mild analgesics with an anti-inflammatory component of action.
Inventors
- 👤 Pier Giorgio Ferrini
- 👤 Georges Haas
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:23
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/192; C07D295/20; C07D295/205
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
134 words
A 2-amino-5-sulphamoylbenzoic acid amide of the general formula ##SPC5## wherein R 1 denotes identical lower alkyl groups with 1 to 4 C atoms, R 2 denotes hydrogen, lower alkyl or lower alkoxy with up to 4 C atoms or halogen up to atomic number 17, R 3 denotes hydrogen, hydroxyl or lower alkyl with 1 to 4 C atoms, R 4 denotes a group of the formula --COOR' or --COR' wherein R' denotes lower alkyl with 1 to 4 C atoms, lower alkenyl with 3 or 4 C atoms or phenyl, benzyl or phenylethyl which are optionally monosubstituted or disubstituted in the phenyl part by lower alkyl or lower alkoxy with 1 to 4 C atoms in each case, halogen up to atomic number 17 or nitro, and alk denotes 1,2-alkylene with 2-4 C
Claim 2
Dependent Claim
134 words
A 2-amino-5-sulphamoylbenzoic acid amide of the general formula ##SPC5## wherein R 1 denotes identical lower alkyl groups with 1 to 4 C atoms, R 2 denotes hydrogen, lower alkyl or lower alkoxy with up to 4 C atoms or halogen up to atomic number 17, R 3 denotes hydrogen, hydroxyl or lower alkyl with 1 to 4 C atoms, R 4 denotes a group of the formula --COOR' or --COR' wherein R' denotes lower alkyl with 1 to 4 C atoms, lower alkenyl with 3 or 4 C atoms or phenyl, benzyl or phenylethyl which are optionally monosubstituted or disubstituted in the phenyl part by lower alkyl or lower alkoxy with 1 to 4 C atoms in each case, halogen up to atomic number 17 or nitro, and alk denotes 1,2-alkylene with 2-4 C
Claim 3
Dependent Claim
56 words
The compound of claim 1 of the general formula I wherein R 1 is methyl, R 2 is hydrogen, R 3 is hydrogen, ethyl or methyl, R 4 is a group of the formula --COOR' or --COR' wherein R' denotes lower alkyl with 1 to 4 C atoms, allyl, phenyl or benzyl which is optionally nitrated,
Claim 4
Dependent Claim
56 words
The compound of claim 1 of the general formula I wherein R 1 is methyl, R 2 is hydrogen, R 3 is hydrogen or ethyl, R 4 is a group of the formula --COOR' wherein R' denotes lower alkyl with 1 to 4 C atoms, allyl or benzyl which is optionally nitrated in the p-position, and
Claim 5
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-ethoxycarbonyl-piperazine or a
Claim 6
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl-anthraniloyl]-4-propoxycarbonyl-piperazine or a
Claim 7
Dependent Claim
8 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-isobutoxycarbonyl-piperazine or
Claim 8
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-butoxycarbonyl-piperazine or a
Claim 9
Dependent Claim
7 words
The compound of claim 1 being 1-[5-(Dimethylaminosulphamoyl)-anthraniloyl]-4-methoxycarbonyl-piperazine
Claim 10
Dependent Claim
7 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-(p-nitro)-benzyloxycarbonyl-pipe
Claim 11
Dependent Claim
8 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-benzyloxycarbonyl-piperazine or
Claim 12
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-allyloxycarbonyl-piperazine or a
Claim 13
Dependent Claim
7 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-N-ethyl-anthraniloyl]-4-ethoxycarbomyl-piperazin
Claim 14
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-acetyl-piperazine or a
Claim 15
Dependent Claim
9 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-propionylpiperazine or a
Claim 16
Dependent Claim
10 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-phenyl-acetyl piperazine or a
Claim 17
Dependent Claim
15 words
The compound of claim 1 being 1-[5-(Dimethylsulphamoyl)-anthraniloyl]-4-benzoylpiperazine or a therapeutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-19 | 1979-07-21 | 1980-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-19 | 1983-07-21 | 1984-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-19 | 1987-07-21 | 1988-01-20 | $7700.00 | Window Closed / Lapsed |