US3936470A
Expired / Lapsed
US
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1,3-Dioxolan-2-ylmethylimidazoles
Assignee: Janssen Pharmaceutica NV
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Filing: 1975-01-27
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Granted: 1976-02-03
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Expires: 1995-01-27
Abstract
Abstract Novel 1-(2-Ar 1 -4-Ar 2 -1,3-dioxolan-2-ylmethyl)imidazoles, 1-[2-Ar 1 -4-(Ar 2 -oxymethyl)-1,3-dioxolan-2-ylmethyl]imidazoles, 1-[2-Ar 1 -4-(Ar 2 -thiomethyl)-1,3-dioxolan-2-ylmethyl]imidazoles, and 1-[2-Ar 1 -4-(Ar 2 -ethyl)-1,3-dioxolan-2-ylmethyl]imidazoles, useful as antifungal and antibacterial agents.
Inventors
- 👤 Jan Heeres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:36
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/56; A; A01; A01N; A01N43/00; A01N43/48; A01N43/50; C07C; C07C29/00; C07C29/09; C07C29/10; C07C29/103; C07C29/106; C07C29/36; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D249/00; C07D249/02; C07D249/08; C07D303/00; C07D303/02; C07D303/04; C07D303/08; C07D303/12; C07D303/18; C07D303/20; C07D303/22; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/16; C07D317/18; C07D317/22; C07D317/24; C07D317/30
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
122 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##EQU6## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: Ar 1 is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl and loweralkoxyphenyl; Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthyl and halonaphthyl, and wherein substituted phenyl has the meaning of a phenyl group, having thereon from 1 to 3 substituents, independently selected from the group consisting of halo, loweralkyl, loweralkoxy, cyano, phenyl and benzyl; X is a member selected from the group consisting of O, S and CH 2 ; and n is the integer 0 or 1.
Claim 2
Dependent Claim
122 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##EQU6## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: Ar 1 is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl and loweralkoxyphenyl; Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthyl and halonaphthyl, and wherein substituted phenyl has the meaning of a phenyl group, having thereon from 1 to 3 substituents, independently selected from the group consisting of halo, loweralkyl, loweralkoxy, cyano, phenyl and benzyl; X is a member selected from the group consisting of O, S and CH 2 ; and n is the integer 0 or 1.
Claim 3
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(p-fluorophenoxymethyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(p-fluorophenoxymethyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[4-(p-bromophenoxymethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[4-(p-bromophenoxymethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 7
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(p-methoxyphenoxymethyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(p-methoxyphenoxymethyl)-1,3-dioxolan-2-ylmethyl]imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(2-fluorophenoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[2-(2,4-dichlorophenyl)-4-(2-fluorophenoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[4-(4-bromophenoxymethyl)-2-(4-chlorophenyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 12
Dependent Claim
18 words
A chemical compound selected from the group consisting of A-1-[4-(4-bromophenoxymethyl)-2-(4-chlorophenyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
References Cited (Backward Citations)
US3575999A
Cited
US3717655A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-02 | 1979-08-04 | 1980-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-02 | 1983-08-04 | 1984-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-02 | 1987-08-04 | 1988-02-03 | $7700.00 | Window Closed / Lapsed |