US3940434A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dicarboxylic acids and derivatives
Assignee: Novartis Corp
•
Filing: 1973-08-16
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Granted: 1976-02-24
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Expires: 1993-08-16
Abstract
Abstract Benzocycloalkenderivatives substituted in 1-position by carboxyl and carboxyalkyl or two carboxyl groups, and further substituted in the benzene ring by cycloalkyl and optionally other substituents, their esters, amides and pharmaceutically acceptable salts have antiinflammatory and analgesic activity and can be used for the treatment of inflammatory conditions and pain in mammals; a representative embodiment is 1-methoxycarbonyl-5-cyclohexyl-6-chloro-1-indanecarboxylic acid.
Inventors
- 👤 Georges Haas
- 👤 Erwin F. Jenny
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 01:55
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07C; C07C17/00; C07C17/093; C07C17/10; C07C17/12; C07C201/00; C07C201/06; C07C201/08; C07C205/00; C07C205/45; C07C221/00; C07C225/00; C07C225/22; C07C231/00; C07C231/02; C07C61/00; C07C61/16; C07C61/39; C07C69/00; C07C69/74; C07C69/753; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/18; C07D317/20; C07C2601/00; C07C2601/12; C07C2601/14; C07C2601/18
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
89 words
A compound of the formula ##SPC12## wherein A denotes the direct bond or a methylene group, one of the groups R 1 and R 2 denotes hydrogen, halogen, lower alkyl with 1 to 4 carbon atoms, or trifluoromethyl and the other denotes a cycloalkyl group with 4 to 8 carbon atoms, X 1 and X 2 independently of one another denote a carboxyl group or a lower alkoxycarbonyl group with 2 to 5 carbon atoms, and n denotes an integer from 1 to 3, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
89 words
A compound of the formula ##SPC12## wherein A denotes the direct bond or a methylene group, one of the groups R 1 and R 2 denotes hydrogen, halogen, lower alkyl with 1 to 4 carbon atoms, or trifluoromethyl and the other denotes a cycloalkyl group with 4 to 8 carbon atoms, X 1 and X 2 independently of one another denote a carboxyl group or a lower alkoxycarbonyl group with 2 to 5 carbon atoms, and n denotes an integer from 1 to 3, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
80 words
A compound according to cliam 1, wherein one of the groups R 1 and R 2 denotes hydrogen, fluorine, chlorine, methyl, ethyl, or trifluoromethyl and the other denotes a cycloalkyl group with 4 to 8 carbon atoms, the groups X 1 and X 2 independently of one another denote a carboxyl group or a lower alkoxycarbonyl group and A denotes a direct bond or a methylene group, and pharmaceutically acceptable salts of a free carboxylic acid falling under this definition.
Claim 4
Dependent Claim
80 words
A compound according to cliam 1, wherein one of the groups R 1 and R 2 denotes hydrogen, fluorine, chlorine, methyl, ethyl, or trifluoromethyl and the other denotes a cycloalkyl group with 4 to 8 carbon atoms, the groups X 1 and X 2 independently of one another denote a carboxyl group or a lower alkoxycarbonyl group and A denotes a direct bond or a methylene group, and pharmaceutically acceptable salts of a free carboxylic acid falling under this definition.
Claim 5
Dependent Claim
51 words
A compound according to claim 1, wherein the group R 1 is hydrogen or chlorine and R 2 is cyclopentyl, cyclohexyl or cycloheptyl, X 1 denotes a free carboxyl group, X 2 denotes a lower alkoxycarbonyl group, A denotes a direct bond and n denotes 2, and pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
15 words
A compound according to claim 1, which is 1-methoxycarbonyl-5-cyclohexyl-6-chloro-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
15 words
A compound according to claim 1, which is 1-butoxycarbonyl-5-cyclohexyl-6-chloro-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
15 words
A compound according to claim 1, which is 1-methoxycarbonyl-5-cycloheptyl-6-chloro-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
15 words
A compound according to claim 1, which is 1-propoxycarbonyl-5-cycloheptyl-6-chloro-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 10
Dependent Claim
15 words
A compound according to claim 1, which is 1-butoxycarbonyl-5-cycloheptyl-6-chloro-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 11
Dependent Claim
15 words
A compound according to claim 1, which is 1-methoxycarbonyl-5-cyclohexyl-1-indanecarboxylic acid, and pharmaceutically acceptable salts thereof.
Claim 12
Dependent Claim
12 words
A compound according to claim 1, which is 1-methoxycarbonyl-5-cyclohexyl-1-indaneacetic acid ethyl ester.
Claim 13
Dependent Claim
15 words
A compound according to claim 1, which is 1-methoxycarbonyl-5-cyclohexyl-1-indaneacetic acid, and pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim
15 words
A compound according to claim 1, which is 1-carboxy-5-cyclohexyl-1-indaneacetic acid, and pharmaceutically acceptable salts thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-23 | 1979-08-25 | 1980-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-23 | 1983-08-25 | 1984-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-23 | 1987-08-25 | 1988-02-24 | $7700.00 | Window Closed / Lapsed |