US3950332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
α-(N-Substituted amino-N-nitrosoamino)acetamides
Assignee: Sandoz Inc
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Filing: 1973-02-14
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Granted: 1976-04-13
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Expires: 1993-02-14
Abstract
Abstract N-substituted amino-N-nitroso-aminoacetamides, e.g., α-(N-morpholino-N-nitrosoamino)acetamide, are prepared by hydrolyzing the corresponding 3-N-substituted amino-sydnonimines and have been found to be useful as hypotensive/anti-hypertensive and anti-anginal agents.
Inventors
- 👤 Paul L. Anderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 00:16
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/22; C07D295/28; C07D295/30
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
177 words
A compound of the formula ##EQU3## where R 1 represents hydrogen or lower alkyl and R 2 and R 3 each, independently, represent lower alkyl; lower alkenyl; lower alkynyl; ω-hydroxyloweralkyl; or cycloalkyl having 3 to 8 carbon atom; and R 2 and R 3 together with N represent ##EQU4## where n is 4, 5 or 6; p is 0, 1 or 2; X represents -O- or R 7 N< ; where R 7 is hydrogen; lower alkyl; alkanoyl having 2 to 4 carbon atoms; ω-hydroxy lower alkyl; alkoxyalkyl having 1 to 4 carbon atoms substituted with 1 to 4 halogen atoms having an atomic weight between 19 to 36; and R 6 represents hydroxy; halo having an atomic weight of about 19 to 36; lower alkyl; lower alkoxy; alkanoyl having 2 to 4 carbon atoms; alkanoyloxy having 2 to 4 carbon atoms; ω-hydroxy lower alkyl; alkoxyalkyl having 2 to 4 carbon atoms; or lower alkyl having 1 to 4 carbon atoms substituted with 1 to 4 halogen atoms having an atomic weight between about 19 to 36.
Claim 2
Dependent Claim
177 words
A compound of the formula ##EQU3## where R 1 represents hydrogen or lower alkyl and R 2 and R 3 each, independently, represent lower alkyl; lower alkenyl; lower alkynyl; ω-hydroxyloweralkyl; or cycloalkyl having 3 to 8 carbon atom; and R 2 and R 3 together with N represent ##EQU4## where n is 4, 5 or 6; p is 0, 1 or 2; X represents -O- or R 7 N< ; where R 7 is hydrogen; lower alkyl; alkanoyl having 2 to 4 carbon atoms; ω-hydroxy lower alkyl; alkoxyalkyl having 1 to 4 carbon atoms substituted with 1 to 4 halogen atoms having an atomic weight between 19 to 36; and R 6 represents hydroxy; halo having an atomic weight of about 19 to 36; lower alkyl; lower alkoxy; alkanoyl having 2 to 4 carbon atoms; alkanoyloxy having 2 to 4 carbon atoms; ω-hydroxy lower alkyl; alkoxyalkyl having 2 to 4 carbon atoms; or lower alkyl having 1 to 4 carbon atoms substituted with 1 to 4 halogen atoms having an atomic weight between about 19 to 36.
Claim 3
Dependent Claim
30 words
A compound according to claim 1 in which R 2 and R 3 together with N represent ##EQU5## where n, p and R 6 are as defined in claim 1.
Claim 4
Dependent Claim
31 words
A compound according to claim 1 in which R 2 and R 3 together with N represent ##EQU6## where p, R 6 and R 7 are as defined in claim 1.
Claim 5
Dependent Claim
22 words
A compound according to claim 1 which is ##EQU7## where p, R 1 and R 6 are as defined in claim 1.
Claim 6
Dependent Claim
9 words
The compound of claim 2 which is α-(N-piperidino-N-nitrosoamino) acetamide.
Claim 7
Dependent Claim
8 words
The compound of claim 2 which is α-(N-piperidino-N-nitrosoamino)-α-methylacetamide.
Claim 8
Dependent Claim
8 words
The compound of claim 3 which is α-(N-[4-β-hydroxyethylpiperazino]N-nitrosoamino)-α-methylacetamide.
Claim 9
Dependent Claim
9 words
The compound of claim 4 which is α-(N-morpholino-N-nitrosoamino) acetamide.
References Cited (Backward Citations)
US3312690A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-13 | 1979-10-13 | 1980-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-13 | 1983-10-13 | 1984-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-13 | 1987-10-13 | 1988-04-13 | $7700.00 | Window Closed / Lapsed |